| Molecular diversity of anticoagulants from haematophagous animals. | |
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MedLine Citation:
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PMID: 19718463 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To obtain blood meals, haematophagous animals are armed with potent pharmacological molecules to overcome several of their hosts' response systems. Among them, a large number of exogenous anticoagulants which target the haemostatic system have been identified and characterised. Studies on these anticoagulants have expanded our knowledge on the blood coagulation system, and provided a valuable source of antithrombotic therapeutic agents. Advances in genomic, transcriptomic, structural and proteomic tools greatly accelerated the discovery and analysis of the exogenous anticoagulants in recent years. The molecular diversity observed in these molecules is huge and is constantly expanding. In this review, we will provide an overview on the structure, function and mechanism of the exogenous anticoagulants from haematophagous animals and rationalise their molecular diversity. |
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Authors:
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Cho Yeow Koh; R Manjunatha Kini |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Thrombosis and haemostasis Volume: 102 ISSN: 0340-6245 ISO Abbreviation: Thromb. Haemost. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-31 Completed Date: 2009-11-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7608063 Medline TA: Thromb Haemost Country: Germany |
Other Details:
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Languages: eng Pagination: 437-53 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Faculty of Science, National University of Singapore, Science Drive 4, Singapore 117543, Singapore. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Anticoagulants / chemistry*, metabolism Bradykinin / physiology Hemostasis Hirudins / chemistry Insect Proteins / metabolism Invertebrate Hormones / metabolism Models, Molecular Molecular Conformation Molecular Sequence Data Peptide Fragments / physiology Protein Structure, Tertiary Sequence Homology, Amino Acid Structure-Activity Relationship Thrombin / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Hirudins; 0/Insect Proteins; 0/Invertebrate Hormones; 0/Peptide Fragments; 0/chimadanin; 110119-38-5/antistasin; 23815-89-6/bradykinin (1-5); 58-82-2/Bradykinin; EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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