Document Detail


Molecular discrimination of taeniid cestodes.
MedLine Citation:
PMID:  16337179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
DNA approaches are now being used routinely for accurate identification of Echinococcus and Taenia species, subspecies and strains, and in molecular epidemiological surveys of echinococcosis/taeniasis in different geographical settings and host assemblages. The publication of the complete sequences of the mitochondrial (mt) genomes of E. granulosus, E. multilocularis, T. solium and Asian Taenia, and the availability of mtDNA sequences for a number of other taeniid genotypes, has provided additional genetic information that can be used for more in depth phylogenetic and taxonomic studies of these parasites. This very rich sequence information has provided a solid molecular basis, along with a range of different biological, epidemiological, biochemical and other molecular-genetic criteria, for revising the taxonomy of the genus Echinococcus and for estimating the evolutionary time of divergence of the various taxa. Furthermore, the accumulating genetic data has allowed the development of PCR-based tests for unambiguous identification of Echinococcus eggs in the faeces of definitive hosts and in the environment. Molecular phylogenies derived from mtDNA sequence comparisons of geographically distributed samples of T. solium provide molecular evidence for two genotypes, one being restricted to Asia, with the other occurring in Africa and America. Whether the two genetic forms of T. solium differ in important phenotypic characteristics remains to be determined. As well, minor DNA sequence differences have been reported between isolates of T. saginata and Asian Taenia. There has been considerable discussion over a number of years regarding the taxonomic position of Asian Taenia and whether it should be regarded as a genotype, strain, subspecies or sister species of T. saginata. The available molecular genetic data do not support independent species status for Asian Taenia and T. saginata. What is in agreement is that both taxa are closely related to each other but distantly related to T. solium. This is important in public health terms as it predicts that cysticercosis in humans attributable to Asian Taenia does not occur, because cysticercosis is unknown in T. saginata.
Authors:
Donald P McManus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2005-12-05
Journal Detail:
Title:  Parasitology international     Volume:  55 Suppl     ISSN:  1383-5769     ISO Abbreviation:  Parasitol. Int.     Publication Date:  2006  
Date Detail:
Created Date:  2006-02-06     Completed Date:  2006-04-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9708549     Medline TA:  Parasitol Int     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  S31-7     Citation Subset:  IM    
Affiliation:
Molecular Parasitology Laboratory, Division of Infectious Diseases and Immunology, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital. donM@qimr.edu.au
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MeSH Terms
Descriptor/Qualifier:
Animals
Child
DNA, Helminth / analysis
DNA, Mitochondrial / analysis
Echinococcosis / parasitology
Echinococcus / classification*,  genetics*
Female
Genotype
Humans
Polymerase Chain Reaction
Species Specificity
Taenia / classification*,  genetics*
Taeniasis / parasitology
Chemical
Reg. No./Substance:
0/DNA, Helminth; 0/DNA, Mitochondrial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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