Document Detail

Molecular diagnosis of prosthetic joint infection. A review of evidence.
MedLine Citation:
PMID:  15744359     Owner:  NLM     Status:  MEDLINE    
Prosthetic joint infection (PJI) diagnosis includes several classes of verification. Among them, only a few have a stronger independent value, namely intraarticular purulence and communicating fistulas. Other diagnostic methods require careful test combinations, analysis, and interpretation. Molecular based techniques using the polymerase chain reaction (PCR) seem to be a promising PJI diagnostic modality due to its excellent sensitivity, specificity, positive predictive value, and speed. Most of the recent reviewers are in agreement that molecular diagnosis has enough potential for future application in orthopaedics even if there are only a few heterogeneous studies fully supporting this concept. Conversely, at least one study has been published with significantly worse results (sensitivity and specificity less than 0.75). The lack of supporting evidence in the published studies may be closely related to varying PCR laboratory procedures, inappropriate reference standards, and other methodological shortcomings among research centers. It is not yet justifiable to firmly include molecular methods into the present PJI diagnostic schemes. The orthopaedic community must await the results of well-organized ongoing studies before considering inclusion of molecular diagnostics as a PJI diagnostic method. The aim of this paper was to make a survey of current PJI molecular diagnostic techniques in orthopaedics.
Jirí Gallo; Milan Raska; Milos Dendis; Anthony V Florschütz; Milan Kolár
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia     Volume:  148     ISSN:  1213-8118     ISO Abbreviation:  Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-03-08     Completed Date:  2006-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101140142     Medline TA:  Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  123-9     Citation Subset:  IM    
Department of Orthopaedics, Teaching Hospital, Olomouc, Czech Republic.
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MeSH Terms
Arthroplasty, Replacement
Bacteria / classification
Bacterial Infections / diagnosis*,  microbiology
DNA, Bacterial / isolation & purification
Joint Diseases / diagnosis,  microbiology*
Polymerase Chain Reaction*
Prosthesis-Related Infections / diagnosis,  microbiology*
Reg. No./Substance:
0/DNA, Bacterial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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