| Molecular diagnosis in a child with sudden infant death syndrome. | |
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MedLine Citation:
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PMID: 11684219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although sudden infant death syndrome (SIDS) has been associated with long QT syndrome-a genetic disorder that causes arrhythmia-a causal link has not been shown. We screened genomic DNA from a child who died of SIDS and identified a de-novo mutation in KVLQT1, the gene most frequently associated with long QT syndrome. This mutation (C350T) had already been identified in an unrelated family that was affected by long QT syndrome. These results confirm the hypothesis that some deaths from SIDS are caused by long QT syndrome and support implementation of neonatal electrocardiographic screening. |
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Authors:
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P J Schwartz; S G Priori; R Bloise; C Napolitano; E Ronchetti; A Piccinini; C Goj; G Breithardt; E Schulze-Bahr; H Wedekind; J Nastoli |
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Publication Detail:
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Type: Letter; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Lancet Volume: 358 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-30 Completed Date: 2001-12-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: England |
Other Details:
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Languages: eng Pagination: 1342-3 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Female Humans Infant Italy Long QT Syndrome / complications*, genetics* Male Polymorphism, Genetic Sudden Infant Death / diagnosis, etiology* |
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