Document Detail

Molecular diagnosis of hereditary thrombotic disorders.
MedLine Citation:
PMID:  21370157     Owner:  NLM     Status:  In-Data-Review    
Deep vein thrombosis (DVT) can be the result of coagulation pathway defects at the molecular level or damage to the vascular endothelium. Some of the acquired causes of DVT include malignancy, trauma, prolonged immobilization, and pregnancy (1). Thrombophilia can be owing in part to both acquired and inherited defects. The relative risk for thrombosis is increased by estrogen replacement therapy (2) and homocysteinemia (3). Homocysteine metabolism is influenced by the use of alcohol, anticonvulsant drugs, cyclosporine, methotrexate, inadequate dietary vitamin B(12), folate and pyridoxine intake, organ transplantation, and reduced creatinine clearance (4-8). Similar to venous thrombosis, homocysteinemia has genetic factors that influence susceptibility (9-11).
J G Donnelly
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular medicine     Volume:  49     ISSN:  1543-1894     ISO Abbreviation:  Methods Mol. Med.     Publication Date:  2001  
Date Detail:
Created Date:  2011-03-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101123138     Medline TA:  Methods Mol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  413-26     Citation Subset:  -    
Department of Laboratory Medicine, Ottawa Hospital Civic Campus, Ottawa, Ontario, Canada.
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