Document Detail

Molecular diagnosis of hereditary thrombotic disorders.
MedLine Citation:
PMID:  21370157     Owner:  NLM     Status:  In-Data-Review    
Deep vein thrombosis (DVT) can be the result of coagulation pathway defects at the molecular level or damage to the vascular endothelium. Some of the acquired causes of DVT include malignancy, trauma, prolonged immobilization, and pregnancy (1). Thrombophilia can be owing in part to both acquired and inherited defects. The relative risk for thrombosis is increased by estrogen replacement therapy (2) and homocysteinemia (3). Homocysteine metabolism is influenced by the use of alcohol, anticonvulsant drugs, cyclosporine, methotrexate, inadequate dietary vitamin B(12), folate and pyridoxine intake, organ transplantation, and reduced creatinine clearance (4-8). Similar to venous thrombosis, homocysteinemia has genetic factors that influence susceptibility (9-11).
J G Donnelly
Related Documents :
22195987 - Circulating lh/hcg receptor (lhcgr) may identify pre-treatment ivf patients at risk of ...
17885457 - Bariatric surgery and adolescent gynecology.
21998337 - Risk of adverse pregnancy outcomes in women with polycystic ovary syndrome: population ...
22284957 - Delivery of monochorionic twins in the absence of complications: analysis of neonatal o...
15522067 - Late puerperal thrombohemorrhagic complications in a patient with antiphospholipid synd...
17143577 - Pregnancy and lactation in a woman with classical galactosaemia heterozygous for p.q188...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular medicine     Volume:  49     ISSN:  1543-1894     ISO Abbreviation:  Methods Mol. Med.     Publication Date:  2001  
Date Detail:
Created Date:  2011-03-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101123138     Medline TA:  Methods Mol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  413-26     Citation Subset:  -    
Department of Laboratory Medicine, Ottawa Hospital Civic Campus, Ottawa, Ontario, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ultrasensitive Quantitation of Human Immunodeficiency Virus Type 1 RNA in Plasma by the AMPLICOR and...
Next Document:  Prenatal Genotyping of the RhD Locus to Identify Fetuses at Risk for Hemolytic Disease of the Newbor...