| Molecular diagnosis of hereditary thrombotic disorders. | |
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MedLine Citation:
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PMID: 21370157 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Deep vein thrombosis (DVT) can be the result of coagulation pathway defects at the molecular level or damage to the vascular endothelium. Some of the acquired causes of DVT include malignancy, trauma, prolonged immobilization, and pregnancy (1). Thrombophilia can be owing in part to both acquired and inherited defects. The relative risk for thrombosis is increased by estrogen replacement therapy (2) and homocysteinemia (3). Homocysteine metabolism is influenced by the use of alcohol, anticonvulsant drugs, cyclosporine, methotrexate, inadequate dietary vitamin B(12), folate and pyridoxine intake, organ transplantation, and reduced creatinine clearance (4-8). Similar to venous thrombosis, homocysteinemia has genetic factors that influence susceptibility (9-11). |
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Authors:
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J G Donnelly |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Methods in molecular medicine Volume: 49 ISSN: 1543-1894 ISO Abbreviation: Methods Mol. Med. Publication Date: 2001 |
Date Detail:
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Created Date: 2011-03-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101123138 Medline TA: Methods Mol Med Country: United States |
Other Details:
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Languages: eng Pagination: 413-26 Citation Subset: - |
Affiliation:
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Department of Laboratory Medicine, Ottawa Hospital Civic Campus, Ottawa, Ontario, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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