| Molecular diagnosis of Huntington's disease in Mexican patients by polymerase chain reaction. | |
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MedLine Citation:
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PMID: 8867374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three highly informative markers genetically linked to Huntington's Disease (HD) were used for diagnosis of HD in Mexican patients, two polymorphic HindIII sites located at D4S10 locus and one VNTR marker at D4S111 locus (VNTR-111). Forty chromosomes from healthy subjects were tested in order to evaluate the informativeness of the probes. The RFLP HindIII 1 and 2 and the VNTR-111 probes showed a heterozygosity of 0%, 45%, and 60%, respectively. Five families were analyzed, of these, only in two the markers used were informative. In one of them, six members showed a decreased risk of inheritance of the mutant gene for Huntington's Disease with 95% accuracy (1). |
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Authors:
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B Cisneros Vega; M E Alonso Vilatela; P Yescas Gomez; G Silva Arreola; C Montañez Ojeda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of medical research Volume: 27 ISSN: 0188-4409 ISO Abbreviation: Arch. Med. Res. Publication Date: 1996 |
Date Detail:
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Created Date: 1996-11-15 Completed Date: 1996-11-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9312706 Medline TA: Arch Med Res Country: MEXICO |
Other Details:
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Languages: eng Pagination: 87-92 Citation Subset: IM |
Affiliation:
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Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del IPN, México. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Base Sequence Female Humans Huntington Disease / diagnosis*, genetics* Male Mexico Middle Aged Molecular Sequence Data Pedigree Polymerase Chain Reaction* Polymorphism, Genetic |
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