Document Detail

Molecular detection of deletions involving band q14 of chromosome 13 in retinoblastomas.
MedLine Citation:
PMID:  2876425     Owner:  NLM     Status:  MEDLINE    
DNA fragments from a locus spanning 29 kilobases within chromosome band 13q14 detected deletions in 3 retinoblastomas out of 37 such tumors examined. Somatically occurring, homozygous deletions spanning at least 25 kilobases were detected in retinoblastomas from two unrelated patients. These deletions are bounded by the esterase D locus proximally. In a third patient, both tumor cells and leukocytes have a deletion of one chromosome 13 homolog, with one end of the deletion localized to a 1.55-kilobase fragment within the cloned region. It is likely that the cloned locus is within a few hundred kilobases of the retinoblastoma gene (i.e., the locus governing predisposition to such tumors) and that the deletions detected also involve the retinoblastoma gene. Further, it may be possible to base a successful approach to the isolation of the retinoblastoma gene on this assumed physical proximity of the two loci.
T P Dryja; J M Rapaport; J M Joyce; R A Petersen
Related Documents :
16552425 - Deletions of 2q14 that include the homeobox engrailed 1 (en1) transcription factor are ...
7645605 - Parental origin of de novo chromosome 9 deletions in del(9p) syndrome.
3706405 - Distal deletion of the long arm of chromosome 6: a specific phenotype?
20870045 - A 797 kb de novo deletion of 18q21.31 in a patient with speech delay, mental retardatio...
4011445 - The molecular karyotype of leishmania major and mapping of alpha and beta tubulin gene ...
16474985 - Substitution rate heterogeneity and the male mutation bias.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  83     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-10-30     Completed Date:  1986-10-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  7391-4     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Chromosome Deletion*
Chromosome Mapping
Chromosomes, Human, Pair 13*
Polymorphism, Restriction Fragment Length
Retinoblastoma / genetics*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Genetic linkage between the antigenic group (Ag) variation and the apolipoprotein B gene: assignment...
Next Document:  Polymorphisms in the human haptoglobin gene cluster: chromosomes with multiple haptoglobin-related (...