Document Detail

Molecular cytogenetics as a diagnostic tool for typing melanocytic tumors.
MedLine Citation:
PMID:  12079244     Owner:  NLM     Status:  MEDLINE    
The melanocyte can give rise to a variety of both benign and malignant lesions that differ in their clinical and histopathological appearance. It is likely that genetic changes underlie this phenotypic diversity. Comparative genomic hybridization (CGH) is a genome-wide scanning technique that permits the measurement of copy number aberrations in archival tumors. Using CGH, we have demonstrated significant differences in the frequency of chromosomal aberrations in primary cutaneous melanomas and Spitz nevi. Whereas the majority of melanomas have aberrations frequently involving chromosomes 9, 10, 7, and 6, most Spitz nevi do not show aberrations. However, a small subset of Spitz nevi show an isolated gain of the short arm of chromosome 11p. As this aberration has not been observed in melanomas, the measurement of chromosomal aberrations should be further evaluated as a diagnostic tool for ambiguous melanocytic tumors.
Boris C Bastian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer     Volume:  160     ISSN:  0080-0015     ISO Abbreviation:  Recent Results Cancer Res.     Publication Date:  2002  
Date Detail:
Created Date:  2002-06-24     Completed Date:  2002-12-12     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0044671     Medline TA:  Recent Results Cancer Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  92-9     Citation Subset:  IM    
Comprehensive Cancer Center and Department of Dermatology and Pathology, University of California, San Francisco 94115, USA.
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MeSH Terms
DNA, Neoplasm / genetics
Melanoma / classification,  diagnosis,  genetics,  pathology*
Nucleic Acid Hybridization
Reg. No./Substance:
0/DNA, Neoplasm

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