| Molecular cytogenetic analysis of Korean patients with Waldenstr?m macroglobulinemia. | |
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MedLine Citation:
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PMID: 20193844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To compare the molecular cytogenetic characteristics between Waldenstr?m macroglobulinemia (WM) and multiple myeloma (MM), we performed interphase fluorescent in situ hybridization (FISH) in Korean patients with WM and MM. Forty patients with WM and 132 patients with MM were enrolled onto the study. FISH was performed with seven different probes: 6q21, 6q23, CEP4, CEP9, immunoglobulin (IgH) breakapart, RB1 gene, and 1q25. Out of 22 WM patients, 4 (18%) had abnormal karyotypes, mainly structural changes on conventional karyotyping. After performing FISH for the available 29 cases, deletions of 6q23 and 6q21 were newly detected in 3 cases (10%). There was no other anomaly, including trisomy 4 in WM. No 6q deletion was observed in MM patients, but RB1 deletion was the most common change (45%), followed by IgH translocation (42%) and gain of 1q (38%). In conclusion, Korean WM patients had a low rate of 6q deletion (10%) and no trisomy 4. |
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Authors:
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Soo-Mee Bang; Ji-Weon Seo; Kyung Un Park; Seok Jin Kim; Kihyun Kim; Sun-Hee Kim; Sung Ran Cho; Hugh C Kim; Jaewoo Song; Jin Seok Kim; Kyung Hee Kim; Jae Hoon Lee; Je-Jung Lee; Myung Geun Shin; Cheolwon Suh; Hyun Sook Chi; Do-Yeun Oh; Jong-Ho Won; Hyo Jung Kim; Sung-Soo Yoon; Dong Soon Lee; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer genetics and cytogenetics Volume: 197 ISSN: 1873-4456 ISO Abbreviation: Cancer Genet. Cytogenet. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-02 Completed Date: 2010-04-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909240 Medline TA: Cancer Genet Cytogenet Country: United States |
Other Details:
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Languages: eng Pagination: 117-21 Citation Subset: IM |
Affiliation:
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Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, Gyeongi-do, 463-707, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Bone Marrow Cells / pathology Chromosome Aberrations* Chromosomes, Human, Pair 6 Cohort Studies Female Gene Deletion Humans Immunoglobulin Heavy Chains / genetics In Situ Hybridization, Fluorescence / methods Karyotyping Korea Male Middle Aged Multiple Myeloma / genetics Waldenstrom Macroglobulinemia / genetics*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin Heavy Chains |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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