Document Detail

Molecular components of the Mammalian circadian clock.
MedLine Citation:
PMID:  23604473     Owner:  NLM     Status:  MEDLINE    
Mammals synchronize their circadian activity primarily to the cycles of light and darkness in the environment. This is achieved by ocular photoreception relaying signals to the suprachiasmatic nucleus (SCN) in the hypothalamus. Signals from the SCN cause the synchronization of independent circadian clocks throughout the body to appropriate phases. Signals that can entrain these peripheral clocks include humoral signals, metabolic factors, and body temperature. At the level of individual tissues, thousands of genes are brought to unique phases through the actions of a local transcription/translation-based feedback oscillator and systemic cues. In this molecular clock, the proteins CLOCK and BMAL1 cause the transcription of genes which ultimately feedback and inhibit CLOCK and BMAL1 transcriptional activity. Finally, there are also other molecular circadian oscillators which can act independently of the transcription-based clock in all species which have been tested.
Ethan D Buhr; Joseph S Takahashi
Related Documents :
2661513 - A model proposing synaptic and extra-synaptic influences on the responses of cochlear n...
24083423 - Synaptophysin is involved in resetting of the mammalian circadian clock.
15627583 - Differential amygdala responses to happy and fearful facial expressions depend on selec...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Handbook of experimental pharmacology     Volume:  -     ISSN:  0171-2004     ISO Abbreviation:  Handb Exp Pharmacol     Publication Date:  2013  
Date Detail:
Created Date:  2013-04-22     Completed Date:  2013-07-23     Revised Date:  2013-09-10    
Medline Journal Info:
Nlm Unique ID:  7902231     Medline TA:  Handb Exp Pharmacol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  3-27     Citation Subset:  IM    
Department of Ophthalmology, University of Washington, 1959 NE Pacific St, 356485 BB-857 HSB, Seattle, WA 98195, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
ARNTL Transcription Factors / physiology
CLOCK Proteins / physiology
Circadian Clocks / physiology*
Suprachiasmatic Nucleus / physiology
Transcription, Genetic
Grant Support
//Howard Hughes Medical Institute
Reg. No./Substance:
0/ARNTL Transcription Factors; EC Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Regulation of pro-angiogenic tissue factor expression in hypoxia-induced human lung cancer cells.
Next Document:  The epigenetic language of circadian clocks.