Document Detail


Molecular components of the Mammalian circadian clock.
MedLine Citation:
PMID:  23604473     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mammals synchronize their circadian activity primarily to the cycles of light and darkness in the environment. This is achieved by ocular photoreception relaying signals to the suprachiasmatic nucleus (SCN) in the hypothalamus. Signals from the SCN cause the synchronization of independent circadian clocks throughout the body to appropriate phases. Signals that can entrain these peripheral clocks include humoral signals, metabolic factors, and body temperature. At the level of individual tissues, thousands of genes are brought to unique phases through the actions of a local transcription/translation-based feedback oscillator and systemic cues. In this molecular clock, the proteins CLOCK and BMAL1 cause the transcription of genes which ultimately feedback and inhibit CLOCK and BMAL1 transcriptional activity. Finally, there are also other molecular circadian oscillators which can act independently of the transcription-based clock in all species which have been tested.
Authors:
Ethan D Buhr; Joseph S Takahashi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Handbook of experimental pharmacology     Volume:  -     ISSN:  0171-2004     ISO Abbreviation:  Handb Exp Pharmacol     Publication Date:  2013  
Date Detail:
Created Date:  2013-04-22     Completed Date:  2013-07-23     Revised Date:  2013-09-10    
Medline Journal Info:
Nlm Unique ID:  7902231     Medline TA:  Handb Exp Pharmacol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  3-27     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, University of Washington, 1959 NE Pacific St, 356485 BB-857 HSB, Seattle, WA 98195, USA.
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MeSH Terms
Descriptor/Qualifier:
ARNTL Transcription Factors / physiology
Animals
CLOCK Proteins / physiology
Circadian Clocks / physiology*
Humans
Suprachiasmatic Nucleus / physiology
Temperature
Transcription, Genetic
Grant Support
ID/Acronym/Agency:
//Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/ARNTL Transcription Factors; EC 2.3.1.48/CLOCK Proteins
Comments/Corrections

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