Document Detail


Molecular cloning and sequencing of sulfated glycoprotein-2 cDNA from testis of mouse: implications of two different mRNAs of SGP-2.
MedLine Citation:
PMID:  8352774     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We cloned a mouse homolog of sulfated glycoprotein-2 (SGP-2) cDNA by screening a mouse testicular cDNA library and its nucleotide sequence was determined. The predicted amino acid sequence of the cDNA shares 93% identity with that of rat SGP-2. The nucleotide sequences of both cDNAs show extensive homology throughout the open reading frames and 3' untranslated regions. The 5' untranslated regions, however, share homology only up to 28 bp upstream from the start codons; the rest of sequences are quite different. DNA sequence homology search to mouse SGP-2 cDNA through the EMBL/GenBank database and a recent study on the genomic organization of rat TRPM-2 gene suggest a possibility that there are at least two different SGP-2 mRNAs as a result of alternative splicing and/or different promoter usage in mouse.
Authors:
K H Lee; Y M Ji; H M Lim; S C Lee; K H You
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  194     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-09-15     Completed Date:  1993-09-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1175-80     Citation Subset:  IM    
Affiliation:
Department of Biology, College of Natural Sciences, College of Pharmacy, Chungnam National University, Taejon, Korea.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/D14017;  D14077;  S63834;  S63835;  S63836;  S63837;  S63838;  S64544;  U11085;  U11086;  U11087
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MeSH Terms
Descriptor/Qualifier:
Alternative Splicing
Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
Clusterin
Exons / genetics
Gene Library
Glycoproteins / genetics*
Male
Mice
Molecular Chaperones*
Molecular Sequence Data
Promoter Regions, Genetic / genetics
RNA, Messenger / genetics*
Sequence Analysis, DNA
Sequence Homology, Nucleic Acid
Testis / chemistry*
Chemical
Reg. No./Substance:
0/Clu protein, mouse; 0/Clusterin; 0/Glycoproteins; 0/Molecular Chaperones; 0/RNA, Messenger

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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