| Molecular cloning, sequence, function and structural basis of human heart 150 kDa oxygen-regulated protein, an ER chaperone. | |
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MedLine Citation:
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PMID: 17131193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Apoptosis of heart tissues followed by hypoxia and ischemia leads finally to cardiac insufficiency. The full-length coding sequence of 3301 bp including cDNA(s) of the ER chaperone ORP150, which was specifically induced by hypoxia stress, was cloned from human cardiac infarct. Phylogenetic analyses reveal that human heart ORP150 shares a highly conserved N-terminal ATPase domain among its related family members. Moreover, hydropathic profiling reveals that their ca. 70 N-terminal residues and unique C-terminal halves exhibit similar hydropathy profiles among members. These findings suggest that ORP150 is structurally and functionally well conserved in distant species. |
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Authors:
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Satoru Takeuchi |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The protein journal Volume: 25 ISSN: 1572-3887 ISO Abbreviation: Protein J. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-07 Completed Date: 2007-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101212092 Medline TA: Protein J Country: Netherlands |
Other Details:
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Languages: eng Pagination: 517-28 Citation Subset: IM |
Affiliation:
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Department of Protein Research, Hibergenome (formerly ProstaColon), 85 NE, Takamatsu, Kahoku, Ishikawa, 929-1215, Japan. prostacolon@yahoo.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphatases
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chemistry Base Sequence Brain / metabolism Cloning, Molecular Endoplasmic Reticulum / metabolism* Humans Molecular Chaperones / chemistry*, genetics Molecular Sequence Data Myocardial Infarction / metabolism Myocardium / chemistry*, metabolism Phylogeny Protein Conformation Protein Structure, Secondary Protein Structure, Tertiary Proteins / chemistry*, genetics, isolation & purification |
| Chemical | |
Reg. No./Substance:
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0/Molecular Chaperones; 0/Proteins; 0/oxygen-regulated proteins; EC 3.6.1.-/Adenosine Triphosphatases |
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