Document Detail

Molecular cloning of the human histamine H1 receptor gene.
MedLine Citation:
PMID:  8003029     Owner:  NLM     Status:  MEDLINE    
The human histamine H1 receptor gene, an intron-lacking gene, was isolated with bovine H1 receptor cDNA [Yamashita, M., Fukui, H., Sugama, K., Horio, Y., Ito, S., Mizuguchi, H., and Wada, H. (1991) Proc. Natl. Acad. Sci. USA 88, 11515-11519] used as a probe. The receptor protein deduced from the nucleotide sequence of this gene was composed of 487 amino acid residues with a calculated Mr of 55,781 and possessed characteristic properties of GTP binding protein-coupled receptors. At the 5' flanking region of the human H1 receptor gene, we located potential TATA box and CACCC sequences, AP1 binding site-like sequences, glucocorticoid responsive element-like sequences, and other binding sequences for inducers. Northern blot analysis showed that H1 receptor mRNAs visualized as two bands with 3.0-kilobase and 3.5-kilobase nucleotides were expressed in peripheral tissues such as placenta, lung, skeletal muscle, and kidney and that only one species with 3.5-kilobase nucleotides was present in the brain. H1 receptor mRNA was most abundant in the placenta. The human H1 receptor gene was mapped to the chromosome 3p25 by the fluorescence in situ hybridization method.
H Fukui; K Fujimoto; H Mizuguchi; K Sakamoto; Y Horio; S Takai; K Yamada; S Ito
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  201     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-07-14     Completed Date:  1994-07-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  894-901     Citation Subset:  IM    
Department of Pharmacology II, Faculty of Medicine, Osaka University, Suita, Japan.
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MeSH Terms
Amino Acid Sequence
Base Sequence
Blotting, Northern
Chromosome Mapping
Chromosomes, Human, Pair 3*
Cloning, Molecular / methods
Genomic Library
Hominidae / genetics*
Molecular Sequence Data
Oligonucleotide Probes
Organ Specificity
Placenta / metabolism
RNA, Messenger / analysis
Receptors, Histamine H1 / biosynthesis,  genetics*
Reg. No./Substance:
0/Oligonucleotide Probes; 0/RNA, Messenger; 0/Receptors, Histamine H1

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