Document Detail


Molecular cloning and expression analysis of CD127 in pig.
MedLine Citation:
PMID:  19160087     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CD127 (the alpha chain of the IL-7 receptor) is an 80 kDa type I membrane glycoprotein that mediates the signal for the differentiation, maturation, and survival of lymphocyte development. In this study, the full-length cDNA of pig Cd127 was cloned and sequenced. Pig CD127 cDNA contains an open reading frame (1,380 bp) encoding 459 amino acids. Phylogenetic analysis revealed that pig CD127 is most homologous to that of cow (Bos taurus) with 87% amino acid identity and less homologous to that of chicken (Gallus gallus) with 36% amino acid identity among those of species. Structurally, pig CD127 has well-conserved cytoplasmic tail that transmits a signal and little diversity of extracellular domain, compared with those of other mammalian species. Expression analysis indicates that the mRNA transcript of pig CD127 is mainly detected in lymphoid tissues, but still detected in nonlymphoid tissues. Future studies will be focused on determining a more defined expression pattern of pig CD127 and the role of CD127 during the lymphocyte development in pigs.
Authors:
Yu Jin Hur; Jong-Gun Kim; Kwang Youn Whang; Young Bong Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Animal biotechnology     Volume:  20     ISSN:  1532-2378     ISO Abbreviation:  Anim. Biotechnol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-01-22     Completed Date:  2009-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011409     Medline TA:  Anim Biotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  40-5     Citation Subset:  IM    
Affiliation:
Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AM498633
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MeSH Terms
Descriptor/Qualifier:
Animals
Cloning, Molecular
Gene Expression Regulation / physiology*
Interleukin-7 Receptor alpha Subunit / genetics*,  metabolism*
Molecular Sequence Data
Swine / genetics*,  physiology
Chemical
Reg. No./Substance:
0/Interleukin-7 Receptor alpha Subunit

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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