Document Detail


Molecular cloning and comparison of avian preproghrelin genes.
MedLine Citation:
PMID:  17347866     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report cDNA sequences for the preproghrelin gene from goose, duck, and emu. This gene is involved in stimulating the release of growth hormone in mammals and may play a similar role in avian species. The complete coding sequence of avian preproghrelin encodes a 116 amino acid (aa) protein, which is organized into three parts: the N-terminal hydrophobic signal peptide, a 26 aa peptide for mature ghrelin, and a long C-terminal polypeptide. Domain/motif structures of preproghrelin protein are highly conserved among avian species. Although the avian and mammalian homologs are not highly similar for the whole 116 aa sequence, the identity of the highly conserved "active core" sequence and the n-octanoyl modification of the serine 3 residue avian ghrelin protein with its mammalian homologs implies conserved function of ghrelin protein during evolution. Information provided in this study will be useful in further studies to determine the role the preproghrelin gene plays in the regulation of growth hormone release and body weight gain in avian species.
Authors:
Jing Yuan; Jianjun Zhou; Xiaoxiang Hu; Ning Li
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-08
Journal Detail:
Title:  Biochemical genetics     Volume:  45     ISSN:  0006-2928     ISO Abbreviation:  Biochem. Genet.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-22     Completed Date:  2007-08-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0126611     Medline TA:  Biochem Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  185-94     Citation Subset:  IM    
Affiliation:
State Key Laboratory for Agrobiotechnology, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian District, Beijing 100094, P.R. China.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AY338465;  AY338466;  AY338467
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Base Sequence
Birds / genetics*
Cloning, Molecular
Ghrelin
Molecular Sequence Data
Peptide Hormones / chemistry,  genetics*
Phylogeny
Protein Precursors / chemistry,  genetics*
Sequence Alignment
Chemical
Reg. No./Substance:
0/Ghrelin; 0/Peptide Hormones; 0/Protein Precursors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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