Document Detail


Molecular cloning and characterization of CRLM-2, a novel type I cytokine receptor preferentially expressed in hematopoietic cells.
MedLine Citation:
PMID:  10872831     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A murine expressed sequence tag (EST) showing homology with erythropoietin receptor (EPOR) was identified in the EST database. Cloning of the full-length cDNA revealed a 359 amino acid novel type I cytokine receptor, designated cytokine receptor like molecule-2 (CRLM-2). While CRLM-2 lacks typical WSXWS motif, it has a significant homology with EPOR, IL-2 receptor beta and gamma, and IL-9 receptor alpha. The murine CRLM-2 gene is composed of 8 exons, and an alternative mRNA splicing generates a variant transcript encoding a soluble CRLM-2. CRLM-2 is preferentially expressed in hematopoietic cells, particularly in hematopoietic progenitors and myeloid cells. Furthermore, CRLM-2 is constitutively associated with JAK2, a well-known tyrosine kinase that transmits signals from cytokine receptors. These data strongly suggest that CRLM-2 is a novel cytokine receptor involved in the regulation of hematopoietic system.
Authors:
T Hiroyama; A Iwama; Y Morita; Y Nakamura; A Shibuya; H Nakauchi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  272     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-07-17     Completed Date:  2000-07-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  224-9     Citation Subset:  IM    
Affiliation:
Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba, and CREST (JST), Ibaraki, Japan.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AB039945
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MeSH Terms
Descriptor/Qualifier:
Alternative Splicing
Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
DNA Primers / genetics
DNA, Complementary / genetics
Gene Expression
Hematopoietic System / immunology*
Mice
Molecular Sequence Data
RNA, Messenger / genetics,  metabolism
Receptors, Cytokine / genetics*
Sequence Homology, Amino Acid
Signal Transduction
Chemical
Reg. No./Substance:
0/DNA Primers; 0/DNA, Complementary; 0/RNA, Messenger; 0/Receptors, Cytokine; 0/Tslpr protein, mouse

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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