Document Detail


Molecular cloning of canine thrombomodulin cDNA and expression in normal tissues.
MedLine Citation:
PMID:  15585960     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thrombomodulin (TM) is a glycoprotein localized mainly on endothelial cell surfaces, and is a major regulator of vascular thromboresistance. The entire open reading frame of canine TM cDNA comprises 1737 bp, encoding 578 amino acid residues. Comparison of the deduced amino acid sequence from canine TM with those of human, mouse, rat, rabbit and bovine (partial) TM sequences revealed 73.1%, 69.1%, 65.8%, 74.3% and 69.5% identity, respectively. Canine TM mRNA expression was confirmed by RT-PCR analysis in lung, liver, spleen, kidney, pancreas and lymph node, and was relatively low in heart, cerebrum, urinary bladder and uterus. The present results provide valuable data for research into canine coagulation disorders.
Authors:
Haruhiko Maruyama; Keisuke Oguma; Sadatoshi Maeda; Rui Kano; Hajime Tsujimoto; Toshihiro Watari; Mikihiko Tokuriki; Atsuhiko Hasegawa
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  66     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-12-08     Completed Date:  2005-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1423-7     Citation Subset:  IM    
Affiliation:
Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, Nihon University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
DNA, Complementary / chemistry,  metabolism
Dogs / genetics,  metabolism*
Male
Molecular Sequence Data
Sequence Homology, Amino Acid
Thrombomodulin / biosynthesis*,  chemistry,  genetics*
Chemical
Reg. No./Substance:
0/DNA, Complementary; 0/Thrombomodulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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