Document Detail

Molecular cloning and analysis of chromosome band 11q23 involved in leukaemia-associated translocations.
MedLine Citation:
PMID:  1384678     Owner:  NLM     Status:  MEDLINE    
Three overlapping yeast artificial chromosomes (YACs) spanning a 780 kb region of DNA around the CD3 locus on chromosome 11 have been isolated and characterised. The individual cloned regions have been mapped by in situ hybridisation to chromosome band 11q23, and a restriction enzyme map of this region has been constructed. The positions of these clones in relation to a series of leukaemia-associated chromosomal translocations has also been determined. It was concluded that, although two clones lay entirely proximal to the breakpoints examined, the third clone (13HH4) encompassed the breakpoints for the translocations t(4;11), t(6;11), and t(9;11). The t(9;11) was observed in an acute myeloid leukaemia in a patient previously treated for an unrelated malignancy. It would thus appear that the breakpoints at chromosome band 11q23 occurring in therapy-related leukaemias are in the same region as those found in adult and childhood acute leukaemias and may result from a common underlying mechanism.
S Das; L Kearney; M Bower; T Chaplin; J H Riley; R Anand; B D Young
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genes, chromosomes & cancer     Volume:  5     ISSN:  1045-2257     ISO Abbreviation:  Genes Chromosomes Cancer     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-12-08     Completed Date:  1992-12-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9007329     Medline TA:  Genes Chromosomes Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  244-51     Citation Subset:  IM    
ICRF Department of Medical Oncology, St. Bartholomew's Hospital, London, England.
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MeSH Terms
Antigens, Differentiation, T-Lymphocyte / genetics
Base Sequence
Blotting, Southern
Chromosomes, Human, Pair 11*
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 9
Cloning, Molecular
In Situ Hybridization, Fluorescence
Leukemia / genetics*
Molecular Sequence Data
Oligonucleotide Probes / genetics
Translocation, Genetic / genetics*
Reg. No./Substance:
0/Antigens, Differentiation, T-Lymphocyte; 0/Oligonucleotide Probes

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