| Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization. | |
| | |
MedLine Citation:
|
PMID: 1849653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PC3 is an immediate early gene induced by nerve growth factor in PC12 cells, a cell line derived from a tumor of the adrenal medulla that undergoes neuronal differentiation in the presence of nerve growth factor. This induction is independent of new protein synthesis as it can occur in the presence of cycloheximide. PC3 is also induced with similar kinetics, but at lower levels, by membrane depolarization (both in vivo and in vitro) and epidermal growth factor. It is induced at much lower levels by fibroblast growth factor and interleukin 6. In vivo it is found expressed in tissues, such as brain at embryonic day 13.5, placenta, amnion, and spleen, which are proliferating and/or differentiating. The deduced protein sequence from the cDNA indicates the presence of a signal peptide, suggesting that PC3 is secreted. |
| | |
Authors:
|
A Bradbury; R Possenti; E M Shooter; F Tirone |
Related Documents
:
|
1992003 - Ngf gene expression in actively growing brain glia. 8076693 - Induction of calbindin-d 28k gene and protein expression by physiological stimuli but n... 12884293 - Vav exchange factor counteracts the hiv-1 nef-mediated decrease of plasma membrane gm1 ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 88 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1991 Apr |
Date Detail:
|
Created Date: 1991-05-15 Completed Date: 1991-05-15 Revised Date: 2010-02-05 |
Medline Journal Info:
|
Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 3353-7 Citation Subset: IM |
Affiliation:
|
Istituto di Neurobiologia, Consiglio Nazionale delle Ricerche, Rome, Italy. |
| Data Bank Information | |
Bank Name/Acc. No.:
|
GENBANK/M60361; M60362; M60363; M60364; M60365; M60366; M60367; M60368; M60369; M60921 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Gland Neoplasms
/
genetics* Amino Acid Sequence Animals Base Sequence Bucladesine / pharmacology Cloning, Molecular DNA / genetics Epidermal Growth Factor / pharmacology Fibroblast Growth Factors / pharmacology Gene Expression / drug effects Immediate-Early Proteins / genetics*, secretion Interleukin-6 / pharmacology Membrane Potentials / drug effects* Molecular Sequence Data Neoplasm Proteins / genetics*, secretion Nerve Growth Factors / pharmacology* Nerve Tissue Proteins / genetics*, secretion Pentylenetetrazole / pharmacology Pheochromocytoma / genetics* Potassium Chloride / pharmacology RNA, Messenger / genetics Rats Restriction Mapping Tetradecanoylphorbol Acetate / pharmacology Tissue Distribution |
| Grant Support | |
ID/Acronym/Agency:
|
NS 04270/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/BTG2 protein, rat; 0/Immediate-Early Proteins; 0/Interleukin-6; 0/Neoplasm Proteins; 0/Nerve Growth Factors; 0/Nerve Tissue Proteins; 0/RNA, Messenger; 16561-29-8/Tetradecanoylphorbol Acetate; 362-74-3/Bucladesine; 54-95-5/Pentylenetetrazole; 62031-54-3/Fibroblast Growth Factors; 62229-50-9/Epidermal Growth Factor; 7447-40-7/Potassium Chloride; 9007-49-2/DNA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Autoantigenicity of Ro/SSA antigen is related to a nucleocapsid protein of vesicular stomatitis viru...
Next Document: Nucleotide sequence and mutation rate of the H strain of hepatitis C virus.