Document Detail


Molecular characterization of thalassemia intermedia in Indians.
MedLine Citation:
PMID:  16956835     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thalassemia intermedia shows considerable heterogeneity. The purpose of this study was to evaluate the prevalence and effect of common molecular determinants in thalassemia intermedia. In 73 cases of thalassemia intermedia, the possible molecular basis was co-existent a-deletions (n=16/50), homozygous XmnI polymorphism (n=17/50), both factors (n=3/50), and milder beta-alleles (n=9/50) in homozygous beta-thalassemia (total 50 cases). In heterozygous beta-thalassemia, alphaalphaalphaanti-3.7 triplication was the predominant factor (14/23 cases).
Authors:
Inusha Panigrahi; Sarita Agarwal; Mandakini Pradhan; Dharma R Choudhry; Ved P Choudhry; Renu Saxena
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Publication Detail:
Type:  Letter; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Haematologica     Volume:  91     ISSN:  1592-8721     ISO Abbreviation:  Haematologica     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-07     Completed Date:  2006-10-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0417435     Medline TA:  Haematologica     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  1279-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Gene Deletion
Humans
India / epidemiology
Molecular Epidemiology
Polymorphism, Genetic
Thalassemia / epidemiology,  genetics*

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