Document Detail


Molecular characterization of pig ST8Sia IV--a critical gene for the formation of neural cell adhesion molecule and its response to sialic acid supplement in piglets.
MedLine Citation:
PMID:  17176637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
ST8Sia IV (polysialyltransferase IV gene) encodes a key enzyme that is required for polysialic acid synthesis. Polysialic acid is a component of the neural cell adhesion molecule and is necessary for synaptic plasticity of neural cells. We characterized 5.3 kb of pig ST8Sia IV cDNA and determined its expression profile in different organs. In hippocampus, ST8Sia IV mRNA levels were increased approximately 4.5-fold in piglets with sialic acid as a milk supplement, which suggested that exogenous sialic acid is a conditionally essential nutrient for early brain development. Extensive analyses were also performed among its orthologs from human, mouse, rat, chicken, frog and zebrafish. Our results supported that the piglet is a better animal model than other nonprimate species in the studies of ST8Sia IV related metabolism and nutrition in human infants. This pig cDNA provides a basis for uncovering the roles of ST8Sia IV during piglet development and maturation.
Authors:
Bing Wang; Honghua Hu; Bing Yu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutritional neuroscience     Volume:  9     ISSN:  1028-415X     ISO Abbreviation:  Nutr Neurosci     Publication Date:    2006 Jun-Aug
Date Detail:
Created Date:  2006-12-20     Completed Date:  2007-02-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892202     Medline TA:  Nutr Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  147-54     Citation Subset:  IM    
Affiliation:
Human Nutrition Unit, School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW, Australia.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Base Sequence
Conserved Sequence
DNA Primers
Dietary Supplements*
Molecular Sequence Data
N-Acetylneuraminic Acid / pharmacokinetics*
Neural Cell Adhesion Molecules / genetics*
Reverse Transcriptase Polymerase Chain Reaction
Sequence Alignment
Sialyltransferases / genetics*
Swine
Chemical
Reg. No./Substance:
0/DNA Primers; 0/Neural Cell Adhesion Molecules; 131-48-6/N-Acetylneuraminic Acid; EC 2.4.99.-/Sialyltransferases; EC 3.4.99.-/ST8Sia IV protein, swine

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