Document Detail

Molecular characterization and marker based chemotaxonomic studies of Podophyllum hexandrum Royle.
MedLine Citation:
PMID:  19788918     Owner:  NLM     Status:  MEDLINE    
Detailed chemical studies and RAPD analysis were done in different populations of Podophyllum hexandrum collected from high altitude regions of North Western Himalayas. Random amplified polymorphic DNA (RAPD) analysis revealed a high degree of genetic diversity among the 12 collected accessions, attributed to their geographical and climatic conditions. HPLC analysis also revealed variation in the concentration of two major marker compounds which lead to the identification of a chemotype. The study demonstrated that RAPD and chemical markers are very useful tools to compare the genetic relationship and pattern of variation among such prioritized and endangered medicinal plants.
Phalisteen Sultan; A S Shawl; Suriya Rehman; S Fayaz Ahmed; P W Ramteke
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Publication Detail:
Type:  Journal Article     Date:  2009-09-26
Journal Detail:
Title:  Fitoterapia     Volume:  81     ISSN:  1873-6971     ISO Abbreviation:  Fitoterapia     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-13     Completed Date:  2010-10-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  16930290R     Medline TA:  Fitoterapia     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  243-7     Citation Subset:  IM    
Copyright Information:
(c) 2009 Elsevier B.V. All rights reserved.
Division of Biotechnology, Indian Institute of Integrative Medicine, formerly, RRL-(CSIR), Sanatnagar, Srinagar 190005, Jammu and Kashmir, India.
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MeSH Terms
Antineoplastic Agents / analysis
Chromatography, High Pressure Liquid
DNA Fingerprinting
DNA, Plant*
Genetic Variation*
Glycosides / analysis
Plant Leaves / chemistry*,  genetics
Podophyllotoxin / analysis,  genetics
Podophyllum / chemistry,  classification,  genetics*
Random Amplified Polymorphic DNA Technique
Reg. No./Substance:
0/Antineoplastic Agents; 0/DNA, Plant; 0/Glycosides; 518-28-5/Podophyllotoxin

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