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MOLECULAR CHARACTERIZATION OF LONG TERMINAL REPEAT SEQUENCES FROM BRAZILIAN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 ISOLATES.
MedLine Citation:
PMID:  23153102     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
HIV-1 provirus activation is under control of the LTR-5´ viral promoter region, which presents remarkable genetic variation among HIV-1 subtypes. It is possible that molecular features of the LTR contribute to the unusual subtype C epidemic profile in Brazilian Southern region. In order to characterize the LTR of Brazilian HIV isolates, we analyzed sequences from 21 infected individuals from Porto Alegre and Salvador cities. Sequences were compared with subtype B and C reference strains from different countries. Phylogenetic analysis showed that 17 (81%) samples were subtype B and four (19%) subtype C. Common patterns of TFBS in subtypes B and C sequences were confirmed and other potential TFBS specific for subtype C were found. Brazilian subtype C sequences contained an additional NF-kappaB biding site, as previously described for the majority of subtype C isolates. The high level of LTR polymorphisms identified in this study might be important for viral fitness.
Authors:
Geraldo Argolo Ferraro; Joana Paixao Monteiro-Cunha; Flora Maria Campos Fernandes; Aline Cristina Andrade Mota-Miranda; Carlos Brites; Luiz Carlos Alcantara; Bernardo Galvão-Castro; Mariza G Morgado
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-15
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  -     ISSN:  1931-8405     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Fundacao Bahiana para Desenvolvimento das Ciencias, Escola Bahiana de Medicina e Saúde Pública, Salvador, Bahia, Brazil; geraldoferraro@bahiana.edu.br.
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