Document Detail


Molecular characterization of interleukin 2.
MedLine Citation:
PMID:  6602719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The isolation of specific T cell growth factors termed interleukin 2 (IL 2) is changing the approach to understanding T cell function. This class of growth factors has allowed te establishment of a number of human and murine T cell lines. We summarize the biochemical properties of human and murine IL 2. Studies have been initiated to isolate mRNA encoding for IL 2. Such RNA can be translated in rabbit reticulocyte lysates yielding IL. 2. This RNA may be useful for the development of probes to isolate lymphokine genes.
Authors:
J D Watson; D Y Mochizuki; S Gillis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Federation proceedings     Volume:  42     ISSN:  0014-9446     ISO Abbreviation:  Fed. Proc.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-08-11     Completed Date:  1983-08-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372771     Medline TA:  Fed Proc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2747-52     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Glycosides / analysis
Humans
Interleukin-2 / genetics,  isolation & purification*
Kinetics
Lymphocyte Activation
Mice
Protein Biosynthesis
RNA, Messenger / genetics
Rabbits
Reticulocytes / metabolism
Species Specificity
Spleen / immunology
T-Lymphocytes / immunology
Chemical
Reg. No./Substance:
0/Glycosides; 0/Interleukin-2; 0/RNA, Messenger

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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