Document Detail


Molecular characterization of identical, novel MLL-EPS15 translocation and individual genomic copy number alterations in monozygotic infant twins with acute lymphoblastic leukemia.
MedLine Citation:
PMID:  22581003     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Translocation of the EPS15 oncogene is rare in infant acute lymphoblastic leukemia, whereas the MLL gene is rearranged in 80% of cases. Molecular characterization of t(1;11)(p32;q23) in a monozygotic infant twin pair with acute lymphoblastic leukemia identified an identical, novel translocation between the MLL and EPS15 loci at both the genomic and transcript level, with the mechanism of DNA repair consistent with non-homologous end joining. Cytogenetic array analysis revealed three common aberrations in leukemia from both twins. Together with the identical breakpoint identified at the fine structural level, this provides further evidence for the in utero development of a pre-leukemic clone in one twin with transfer to the other by means of the shared placental circulation. A number of aberrations, however, were unique and individualized to each twin. Such differences at the molecular level may attribute to the clinical heterogeneity of infant acute lymphoblastic leukemia.
Authors:
Rishi Sury Kotecha; Jette Ford; Alex H Beesley; Denise Anderson; Catherine H Cole; Ursula R Kees
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-11
Journal Detail:
Title:  Haematologica     Volume:  -     ISSN:  1592-8721     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417435     Medline TA:  Haematologica     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Princess Margaret Hospital for Children; Telethon Institute for Child Health Research;
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