Document Detail


Molecular characterization of hepatitis A virus isolated from acute gastroenteritis patients in the Seoul region of Korea.
MedLine Citation:
PMID:  19466614     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hepatitis A virus (HAV) is a major public health problem throughout the world. As a result of declining HAV endemic in Korea, an increasing number of children and adolescents have become susceptible to HAV infection. HAV is related with sanitation conditions of the environment and is transmitted via the fecal-oral route, either through person-to-person contact or by contaminated water and food. The present study has been carried out to determine the phylogenetic analysis and circulating patterns of HAV strains detected from hospitalized patients with acute gastroenteritis (AGE) in the Seoul region of Korea. In total, 2,782 stool specimens from hospitalized patients with AGE collected in October 2006 to September 2007 in Seoul were tested for HAV. A pair comparison of the nucleic acid sequence of a 159-bp base region at the putative VP1/2A junction of 85 Seoul isolates revealed that the most common HAV strain circulating in the region during 2006-2007 was subgenotype IA. HAV phylogenetic studies can provide important information on the genetic characteristics of HAV from AGE patients who may subsequently become the source of infection in Korea.
Authors:
S-H Park; E-J Kim; J-H Lee; S-S Choi; M-S Kim; S-S Jung; G-Y Han; H-S Yun; D-S Chun; S-S Oh; H-S Kim
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Publication Detail:
Type:  Journal Article     Date:  2009-05-26
Journal Detail:
Title:  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology     Volume:  28     ISSN:  1435-4373     ISO Abbreviation:  Eur. J. Clin. Microbiol. Infect. Dis.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-02     Completed Date:  2009-11-09     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8804297     Medline TA:  Eur J Clin Microbiol Infect Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1177-82     Citation Subset:  IM    
Affiliation:
Virus Team, Seoul Metropolitan Government Research Institute of Public Health and Environment, 202-3, Yangjae-Dong, Seocho-Gu, Seoul, 137-734, Republic of Korea. sanghun7@hanmail.net
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AF314208;  AY322886;  AY644676;  L07688;  L07691;  L07729;  L07731;  L07732
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Adult
Base Sequence
Child
Child, Preschool
Feces / virology
Female
Gastroenteritis / epidemiology,  virology*
Genotype
Hepatitis A / epidemiology,  virology*
Hepatitis A Virus, Human / classification*,  genetics*,  isolation & purification
Humans
Infant
Infant, Newborn
Korea
Male
Middle Aged
Molecular Epidemiology
Molecular Sequence Data
Phylogeny
RNA, Viral / chemistry*,  genetics
Reverse Transcriptase Polymerase Chain Reaction
Sequence Alignment
Young Adult
Chemical
Reg. No./Substance:
0/RNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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