Document Detail

Molecular characterization of a t(11;14)(q23;q32) chromosome translocation in a B-cell lymphoma.
MedLine Citation:
PMID:  2143098     Owner:  NLM     Status:  MEDLINE    
We have analyzed the molecular features of a t(11;14)(q23;q32) chromosome translocation of a cell line established from a B-cell lymphoma. Somatic hybrid cells carrying the 11q- and/or 14q+ chromosome(s) were produced in order to map the breakpoints. Southern blot analyses of DNAs from these hybrid cell lines together with various probes from the IGH locus on chromosome 14 and the ETS-1 and CD3 genes on chromosome 11 showed that the breakpoints of the translocation occurred between the constant regions of the C phi gamma and C gamma 2 genes on chromosome 14 and between the CD3 and ETS-1 genes on chromosome 11. The t(11;14)(q23;q32) translocation does not seem to involve the same mechanism that is responsible for translocations occurring at the immunoglobulin heavy chain joining segment (JH).
Y Akao; Y Tsujimoto; J Finan; P C Nowell; C M Croce
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer research     Volume:  50     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-09-12     Completed Date:  1990-09-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4856-9     Citation Subset:  IM    
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.
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MeSH Terms
Antigens, CD / genetics
Antigens, CD3
Antigens, Differentiation, T-Lymphocyte / genetics
B-Lymphocytes / immunology
Blotting, Southern
Cell Line
Chromosome Banding
Chromosomes, Human, Pair 11*
Chromosomes, Human, Pair 14*
DNA / genetics
DNA, Neoplasm / genetics,  isolation & purification
Immunoglobulin Constant Regions / genetics
Lymphoma / genetics*,  immunology
Placenta / analysis
Receptors, Antigen, T-Cell / genetics
Restriction Mapping
Translocation, Genetic*
Grant Support
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD3; 0/Antigens, Differentiation, T-Lymphocyte; 0/DNA, Neoplasm; 0/Immunoglobulin Constant Regions; 0/Receptors, Antigen, T-Cell; 9007-49-2/DNA

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