Document Detail


Molecular characterization of Hepatitis C virus (HCV) core region in HCV-infected Thai blood donors.
MedLine Citation:
PMID:  12580379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to investigate the distribution of Hepatitis C virus (HCV) genotypes in Thailand, we performed phylogenetic analysis based on the virus core region and in this way we identified and reliably distinguished HCV genotypes 1-6 as well as subtypes. Among 100 plasma samples randomly selected from blood donors positive for antibodies to HCV (anti-HCV) 90 (90%) were found positive for HCV RNA and 77 of them were subjected to nucleotide sequencing. The following types and subtypes were identified in this group: 1a in 16 samples (20.8%), 1b in 14 samples (18.2%), 3a in 29 samples (37.7%), 3b in 5 samples (6.5%), and 6a in 13 samples (16.9%). Although this study allowed identification and characterization of HCV among blood donors, more extensive studies are needed to explore the HCV distribution in other population groups and in other geographical regions and to exploit the virus core-based characterization of HCV for evaluation of treatment and clinical outcome and epidemiological purposes.
Authors:
A Theamboonlers; T Chinchai; K Bedi; P Jantarasamee; M Sripontong; Y Poovorawan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta virologica     Volume:  46     ISSN:  0001-723X     ISO Abbreviation:  Acta Virol.     Publication Date:  2002  
Date Detail:
Created Date:  2003-02-12     Completed Date:  2003-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370401     Medline TA:  Acta Virol     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  169-73     Citation Subset:  IM    
Affiliation:
Viral Hepatitis Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
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MeSH Terms
Descriptor/Qualifier:
Blood Donors* / statistics & numerical data
Hepacivirus / genetics*,  isolation & purification
Hepatitis C / epidemiology,  virology*
Humans
Phylogeny
Prevalence
Thailand / epidemiology
Viral Core Proteins / analysis,  genetics
Chemical
Reg. No./Substance:
0/Viral Core Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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