Document Detail


Molecular characterisation and expression of Atlantic cod (Gadus morhua) myoglobin from two populations held at two different acclimation temperatures.
MedLine Citation:
PMID:  17884647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Much previous research has demonstrated the plasticity of myoglobin concentrations in both cardiac and skeletal myocytes in response to hypoxia and training. No study has yet looked at the effect of thermal acclimation on myoglobin in fish. Atlantic cod (Gadus morhua) from two different populations, i.e. the North Sea and the North East Arctic, were acclimated to 10 and 4 degrees C. Both the myoglobin mRNA and myoglobin protein in cod hearts increased significantly by up to 3.7 and 2.3 fold respectively as a result of acclimation to 4 degrees C. These increments were largest in the Arctic population, which in earlier studies have been shown to possess cold compensated metabolic demands at low temperatures. These metabolic demands associated with higher mitochondrial capacities may have driven the increase in cardiac myoglobin concentrations, in order to support diffusive oxygen supply. At the same time the increase in myoglobin levels may serve further functions during cold acclimation, for example, protection of the cell against reactive oxygen species, and scavenging nitric oxide, thereby contributing to the regulation of mitochondrial volume density.
Authors:
Glenn J Lurman; Nils Koschnick; Hans-O Pörtner; Magnus Lucassen
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-08-28
Journal Detail:
Title:  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology     Volume:  148     ISSN:  1095-6433     ISO Abbreviation:  Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-02     Completed Date:  2007-11-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9806096     Medline TA:  Comp Biochem Physiol A Mol Integr Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  681-9     Citation Subset:  IM    
Affiliation:
Alfred-Wegener-Institut fuer Polar-und Meeresforschung, Am Handelshafen 12, 27570, Bremerhaven, Germany. Glenn.Lurman@awi.de
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MeSH Terms
Descriptor/Qualifier:
Acclimatization*
Amino Acid Sequence
Animals
Arctic Regions
Energy Metabolism
Fish Proteins / chemistry,  genetics,  metabolism*
Gadus morhua / metabolism,  physiology*
Mitochondria, Heart / metabolism*
Models, Molecular
Molecular Sequence Data
Myocardium / metabolism*
Myoglobin / chemistry,  genetics,  metabolism*
North Sea
Oxygen / metabolism
Protein Conformation
RNA, Messenger / metabolism
Temperature*
Up-Regulation
Chemical
Reg. No./Substance:
0/Fish Proteins; 0/Myoglobin; 0/RNA, Messenger; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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