| Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility. | |
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MedLine Citation:
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PMID: 20006655 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Steroid hormone receptors (SHRs) are notorious intracellular travellers, transiting among different cellular compartments as they mature, are subjected to regulation and exert their biological functions. Understanding the processes governing the intracellular traffic of SHRs is important, since their unbalanced or erroneous localization could lead to the development of diseases. In this review, we not only explore the functions of the heat-shock protein 90 (Hsp90) molecular chaperone machine for the intracellular transport of SHRs, but also for the regulation of their nuclear mobility, for their recycling and for the regulation of their transcriptional output. |
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Authors:
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Pablo C Echeverria; Didier Picard |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-12-16 |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1803 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-24 Completed Date: 2010-07-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 641-9 Citation Subset: IM |
Affiliation:
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Département de Biologie Cellulaire, Université de Genève, 1211 Genève 4, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Nucleus / metabolism Cytoplasm / metabolism Fungi / metabolism Gene Deletion HSP90 Heat-Shock Proteins / metabolism Humans Ligands Microtubules / metabolism Models, Biological Molecular Chaperones / metabolism* Protein Binding Protein Transport* Receptors, Steroid / metabolism |
| Chemical | |
Reg. No./Substance:
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0/HSP90 Heat-Shock Proteins; 0/Ligands; 0/Molecular Chaperones; 0/Receptors, Steroid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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