Document Detail


Molecular and cellular events at the onset of the lymphoproliferative process induced by HTLV-I (human T-cell leukemia virus, type I).
MedLine Citation:
PMID:  2054528     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The human retrovirology opened its first chapter, 10 years ago, with the isolation and characterization of HTLV-I (Human T-cell leukemia virus, type I), a type C retrovirus, which was found to be etiologically linked first to adult T-cell leukemia and second to neurological disorders. Epidemiological data have indeed shown that patients who developed these diseases represent a small percentage of HTLV-I infected individuals living in restricted geographical areas. Experiments performed at molecular and cellular levels have revealed that HTLV-I plays an essential role in the initiation of the lymphoproliferative process. Indeed, viral particles deliver a mitogenic signal to human resting T lymphocytes. After proviral integration, two regulatory proteins--Tax and Rex--are controlling the replicative cycle of HTLV-I. The Tax protein trans-activates the proviral transcription and the Rex protein is essential in the synthesis of viral structural proteins. Furthermore, the Tax protein induces the transcription of several cellular genes involved in T-cell activation and proliferation. Studies are now aimed at identifying HTLV-I target cells among precursors of the T cell lineage and at unravelling the role of HTLV-I in the secondary events leading to leukemogenesis.
Authors:
L Gazzolo; M Duc Dodon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Bulletin du cancer     Volume:  78     ISSN:  0007-4551     ISO Abbreviation:  Bull Cancer     Publication Date:  1991  
Date Detail:
Created Date:  1991-07-30     Completed Date:  1991-07-30     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0072416     Medline TA:  Bull Cancer     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  291-8     Citation Subset:  IM; X    
Affiliation:
Laboratoire d'immuno-virologie moléculaire et cellulaire, UMR30-CNRS/UCBL, faculté de médecine Alexis-Carrel, Lyon, France.
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MeSH Terms
Descriptor/Qualifier:
Gene Products, rex / metabolism
Gene Products, tax / metabolism
Human T-lymphotropic virus 1 / metabolism*
Humans
Lymphoproliferative Disorders / metabolism,  microbiology*
Viral Envelope Proteins / metabolism
Chemical
Reg. No./Substance:
0/Gene Products, rex; 0/Gene Products, tax; 0/Viral Envelope Proteins

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