| Molecular cell death platforms and assemblies. | |
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MedLine Citation:
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PMID: 20817427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multi-cellular animals have evolved a variety of mechanisms to respond to diverse apoptotic stimuli. In general these proceed through activation of apical caspases and culminate in executioner caspase activation and cell death. Because of the breadth of possible initiators, various molecular platforms are used to trigger different apical caspases. Although some common protein domains are used to assemble the apoptosome, the PIDDosome and death receptor complexes, an array of checks-and-balances are employed to ensure appropriate activation. Notwithstanding, these pathways share the underlying principle of proximity-dependent activation and post-translational modification. Here we will describe our current structural understanding of assembly and regulation of these signaling platforms. |
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Authors:
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Peter D Mace; Stefan J Riedl |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Current opinion in cell biology Volume: 22 ISSN: 1879-0410 ISO Abbreviation: Curr. Opin. Cell Biol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-29 Completed Date: 2011-03-03 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 8913428 Medline TA: Curr Opin Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 828-36 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Program in Apoptosis and Cell Death Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosomes / metabolism Caspases / metabolism Cell Death* Enzyme Activation Models, Molecular Protein Structure, Tertiary Signal Transduction / physiology Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 AA017238/AA/NIAAA NIH HHS; R01 AA017238-03/AA/NIAAA NIH HHS; R01 AA017238-04/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apoptosomes; 0/Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; EC 3.4.22.-/Caspases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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