| Molecular and cell biological aspects of infection by Listeria monocytogenes. | |
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MedLine Citation:
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PMID: 10631564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bacterial pathogens have developed many subtle mechanisms to overcome and exploit cellular processes within the infected eukaryotic host cell. Listeria monocytogenes, a facultative intracellular non-spore forming gram-positive pathogen, uses a number of strategies to ursurp and harness host cell processes to invade, proliferate, move intracellularly and effect cell-to-cell spread during the course of infection. In this review progress in elucidating mechanisms by which the bacteria recruit and use components of the host actin-based cytoskeleton to generate intracellular motility is presented. Analysis of this fascinating property is giving us unexpected glimpses into the molecular mechanisms of complex cellular functions, here in particular, of actin-based cellular motility. Apart from an understanding of the fundamental biology of living processes these studies provide us with novel strategies to combat and halt infections by intracellular bacteria. |
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Authors:
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T Chakraborty |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Immunobiology Volume: 201 ISSN: 0171-2985 ISO Abbreviation: Immunobiology Publication Date: 1999 Dec |
Date Detail:
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Created Date: 2000-02-15 Completed Date: 2000-02-15 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8002742 Medline TA: Immunobiology Country: GERMANY |
Other Details:
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Languages: eng Pagination: 155-63 Citation Subset: IM |
Affiliation:
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Institut für Medizinische Mikrobiologie, Giessen, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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metabolism* Animals Bacterial Proteins / physiology* Cells / microbiology Humans Listeria Infections / microbiology* Listeria monocytogenes / pathogenicity*, physiology* Membrane Proteins / physiology* Movement |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/Bacterial Proteins; 0/Membrane Proteins; 144430-05-7/actA protein, Listeria monocytogenes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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