Document Detail


Molecular call and response: the physiology of bacterial small RNAs.
MedLine Citation:
PMID:  21843668     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The vital role of bacterial small RNAs (sRNAs) in cellular regulation is now well-established. Although many diverse mechanisms by which sRNAs bring about changes in gene expression have been thoroughly described, comparatively less is known about their biological roles and effects on cell physiology. Nevertheless, for some sRNAs, insight has been gained into the intricate regulatory interplay that is required to sense external environmental and internal metabolic cues and turn them into physiological outcomes. Here, we review examples of regulation by selected sRNAs, emphasizing signals and regulators required for sRNA expression, sRNA regulatory targets, and the resulting consequences for the cell. We highlight sRNAs involved in regulation of the processes of iron homeostasis (RyhB, PrrF, and FsrA) and carbon metabolism (Spot 42, CyaR, and SgrS).
Authors:
Gregory R Richards; Carin K Vanderpool
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-08-06
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1809     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-04     Completed Date:  2011-11-23     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  525-31     Citation Subset:  IM    
Copyright Information:
2011 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Carbon / chemistry
Cyclic AMP / metabolism
Escherichia coli / genetics
Gene Expression Regulation, Bacterial
Genes, Bacterial
Homeostasis
Iron / metabolism
Models, Biological
Models, Genetic
RNA, Bacterial / genetics*,  physiology*
RNA, Untranslated / genetics
Grant Support
ID/Acronym/Agency:
R01 GM092830/GM/NIGMS NIH HHS; R01 GM092830-01/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/RNA, Bacterial; 0/RNA, Untranslated; 7440-44-0/Carbon; E0399OZS9N/Cyclic AMP; E1UOL152H7/Iron
Comments/Corrections

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