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Molecular breast cancer subtypes prevalence in an indigenous Sub Saharan African population.
MedLine Citation:
PMID:  25309649     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
INTRODUCTION: Sub-Saharan Africa is predicted to face an unprecedented growth of cancers including breast cancer. There are indications of a significant burden of aggressive and late stage breast disease among premenopausal women in sub-Saharan Africa; because hormonal status tests are not routinely done, many women are given anti-hormonal therapy empirically. There is paucity of data on breast cancer molecular subtypes and their characteristics among women in sub Saharan Africa. The objective is to determine the prevalence of breast cancer molecular phenotypes among Ugandan women.
METHODS: This was a cross sectional descriptive study, conducted at a tertiary hospital in Africa. Eligible participants' formalin fixed and paraffin embedded sections were evaluated. H & E stains and Immunochemistry (Estrogen Receptor (ER), Progesterone Receptor (PR), Human Epidermal growth factor Receptor (HER2)) were performed. Ethical approval was obtained.
RESULTS: A total of 226 patient samples were evaluated. The mean age was 45 years (SD 14);the prevalence of Triple Negative Breast Cancer (TNBC) was 34% (77/226), Luminal A 38% (83/226), HER2 positive was 22% (49/226), and Luminal B was 5% (13/226). High-grade (III) tumors were 68%, stage III and IV constituted 75% of presentations. Histological type was mostly invasive ductal carcinoma. Most patients (55%) were from rural areas.
CONCLUSION: Ugandan women had an over representation of TNBC and high-grade breast tumors. Underlying reasons ought to be investigated. The empirical use of tamoxifen (anti-hormonal therapy) should be reexamined.
Authors:
Moses Galukande; Henry Wabinga; Florence Mirembe; Charles Karamagi; Alexzander Asea
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2014-04-05
Journal Detail:
Title:  The Pan African medical journal     Volume:  17     ISSN:  1937-8688     ISO Abbreviation:  Pan Afr Med J     Publication Date:  2014  
Date Detail:
Created Date:  2014-10-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101517926     Medline TA:  Pan Afr Med J     Country:  Uganda    
Other Details:
Languages:  eng     Pagination:  249     Citation Subset:  IM    
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