Document Detail

Molecular biology in cardiology, a paradigmatic shift.
MedLine Citation:
PMID:  3050135     Owner:  NLM     Status:  MEDLINE    
Control of the performance of the heart can now be understood in terms of three paradigms: beat-to-beat, length-dependent regulation (Starling's Law of the Heart); short term regulation by biochemical changes within the cardiac cell (excitation-contraction coupling, myocardial contractility); and long term regulation by altered gene expression (molecular biology). The latter may also compensate for inhomogeneities in ventricular function. According to Kuhn's theory, the more recent of these paradigms should provide a better and more complete picture of cardiac function. However, because each of these paradigms explains distinct aspects of cardiac regulation that are not mutually exclusive, this evolution fails to support Kuhn's view that science progresses as a series of revolutionary advances. Instead, it is only by understanding all of these paradigms that we can begin to grasp their complex interactions in governing cardiac function, and so gain insight into these interwoven control mechanisms. It seems likely that this is not an uncommon pattern, and that future work will add new paradigms to the complex body of knowledge of cardiac regulation without invalidating any of the paradigms described in this editorial.
A M Katz
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Publication Detail:
Type:  Biography; Historical Article; Journal Article; Portraits; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  20     ISSN:  0022-2828     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-11-08     Completed Date:  1988-11-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  355-66     Citation Subset:  IM; Q    
Department of Medicine, University of Connecticut, Farmington 06032.
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MeSH Terms
Cardiology / history*
Gene Expression Regulation
Heart / physiology
History, 20th Century
Molecular Biology / history*
Myocardial Contraction
Grant Support
Comment In:
J Mol Cell Cardiol. 1991 Apr;23(4):395-402   [PMID:  1942076 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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