Document Detail

Molecular biology-based assessment of vitamin e-coated dialyzer effects on oxidative stress, inflammation, and vascular remodeling.
MedLine Citation:
PMID:  21323683     Owner:  NLM     Status:  In-Data-Review    
Cardiovascular disease represents the most common cause for the excess of morbidity and mortality found in end-stage renal disease (ESRD) and has prompted the exploration of multiple approaches to improve outcomes in these patients. Cardiovascular risk factors such as increased oxidative stress (OxSt) and inflammation are found in ESRD patients. A vitamin E-coated dialyzer using polysulfone membranes has been suggested to have positive effects on these factors. This 1-year study evaluated in 25 ESRD patients under chronic dialysis, the effects of a vitamin E-coated membrane (VitabranE ViE) "ex vivo" on mononuclear cells, OxSt, and inflammation-related biochemical and molecular biology markers using a molecular biology approach. p22(phox) , heme oxygenase (HO)-1, plasminogen activator inhibitor (PAI)-1 protein level, and phosphorylated extracellular signal-regulated kinase (pERK)1/2 status were evaluated at the beginning of the study, after 6 months and after 12 months by Western blot analysis and oxidized low-density lipoprotein (OxLDL) plasma level by enzyme-linked immunosorbent assay, alongside vascular remodeling assessment as measured by carotid intima-media thickness (IMT) in a subgroup of nine randomly selected patients. p22(phox) , PAI-1, OxLDL, and pERK all decreased with VitabranE use, while HO-1 increased. Carotid IMT did not increase. Treatment with VitabranE significantly decreases the expression of proteins and markers relevant to OxSt and inflammation tightly associated with cardiovascular disease, and it appears highly likely that VitabranE use will provide a benefit in terms of cardiovascular protection.
Lorenzo A Calò; Agostino Naso; Angela D'Angelo; Elisa Pagnin; Marco Zanardo; Massimo Puato; Mirka Rebeschini; Silvano Landini; Mariano Feriani; Angelo Perego; Andrea Malagoli; Riccardo Zagatti; Piergianni Calzavara; Carmelo Cascone; Paul A Davis
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Publication Detail:
Type:  Journal Article     Date:  2011-02-14
Journal Detail:
Title:  Artificial organs     Volume:  35     ISSN:  1525-1594     ISO Abbreviation:  Artif Organs     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E33-9     Citation Subset:  IM    
Copyright Information:
© 2011, Copyright the Authors. Artificial Organs © 2011, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.
Department of Clinical and Experimental Medicine and Division of Nephrology, University of Padova-Azienda Ospedaliera di Padova, Padova; Divisions of Nephrology, Hospitals of Mestre (Venezia), Monselice (Padova), and Treviso, Italy; and Department of Nutrition, University of California, Davis, CA, USA.
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