Document Detail


Molecular biology of androgen action in genital hypoplasia associated with congenital growth hormone deficiency: a "transitory androgen insensitivity syndrome"?
MedLine Citation:
PMID:  3675074     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Androgen receptor analyses of foreskin homogenate from a boy with congenital growth hormone deficiency revealed at age 1 and 3 years a decreased number of cytosolic binding sites for testosterone (T) and dihydrotestosterone (DHT), compared with controls of similar age. Nuclear T receptor was not detectable at age 1 but showed abnormal high-binding capacity at age 3 years. Nuclear DHT receptor was within normal limits at both age 1 and 3 years. Receptor affinities were normal. Maximum reaction velocity of tissue-specific androgen 5 alpha-reductase A5R was decreased at age 1 year but within the normal range at age 3 years. Stretched penile length was below the third percentile at age 1 and increased to a 25th percentile at age 3 years, respectively. As the receptor and A5R data seem to indicate a "catch-up" growth, i.e., normalization of the external genitalia, we therefore postulate a "transitory" course of an androgen insensitivity in this particular patient.
Authors:
A Lischka
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of andrology     Volume:  18     ISSN:  0148-5016     ISO Abbreviation:  Arch. Androl.     Publication Date:  1987  
Date Detail:
Created Date:  1987-11-30     Completed Date:  1987-11-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806755     Medline TA:  Arch Androl     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  269-74     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Aging
Cell Nucleus / metabolism
Chorionic Gonadotropin / diagnostic use
Cytosol / metabolism
Dihydrotestosterone / metabolism
Growth Hormone / deficiency*
Humans
Infant, Newborn
Kinetics
Male
Penis / abnormalities*,  metabolism
Receptors, Androgen / drug effects,  metabolism*
Testosterone / metabolism
Testosterone 5-alpha-Reductase / metabolism
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Receptors, Androgen; 521-18-6/Dihydrotestosterone; 58-22-0/Testosterone; 9002-72-6/Growth Hormone; EC 1.3.99.5/Testosterone 5-alpha-Reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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