Document Detail

Molecular biology of androgen action in genital hypoplasia associated with congenital growth hormone deficiency: a "transitory androgen insensitivity syndrome"?
MedLine Citation:
PMID:  3675074     Owner:  NLM     Status:  MEDLINE    
Androgen receptor analyses of foreskin homogenate from a boy with congenital growth hormone deficiency revealed at age 1 and 3 years a decreased number of cytosolic binding sites for testosterone (T) and dihydrotestosterone (DHT), compared with controls of similar age. Nuclear T receptor was not detectable at age 1 but showed abnormal high-binding capacity at age 3 years. Nuclear DHT receptor was within normal limits at both age 1 and 3 years. Receptor affinities were normal. Maximum reaction velocity of tissue-specific androgen 5 alpha-reductase A5R was decreased at age 1 year but within the normal range at age 3 years. Stretched penile length was below the third percentile at age 1 and increased to a 25th percentile at age 3 years, respectively. As the receptor and A5R data seem to indicate a "catch-up" growth, i.e., normalization of the external genitalia, we therefore postulate a "transitory" course of an androgen insensitivity in this particular patient.
A Lischka
Related Documents :
21890824 - Risk factors for childhood mental health symptoms: national longitudinal study of austr...
12934044 - Declining testicular function in aging men.
17107774 - State and trait related predictors of serum cortisol to dhea(s) molar ratios and hormon...
23642384 - Prevalence and prognosis of aortic valve disease in subjects older than 85 years of age.
21079444 - Skeletal age in youth soccer players: implication for age verification.
22215094 - Clinical features, prognostic factors, and their relationship with antiplatelet antibod...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of andrology     Volume:  18     ISSN:  0148-5016     ISO Abbreviation:  Arch. Androl.     Publication Date:  1987  
Date Detail:
Created Date:  1987-11-30     Completed Date:  1987-11-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806755     Medline TA:  Arch Androl     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  269-74     Citation Subset:  IM    
Department of Pediatrics, University of Vienna, Austria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Nucleus / metabolism
Chorionic Gonadotropin / diagnostic use
Cytosol / metabolism
Dihydrotestosterone / metabolism
Growth Hormone / deficiency*
Infant, Newborn
Penis / abnormalities*,  metabolism
Receptors, Androgen / drug effects,  metabolism*
Testosterone / metabolism
Testosterone 5-alpha-Reductase / metabolism
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Receptors, Androgen; 521-18-6/Dihydrotestosterone; 58-22-0/Testosterone; 9002-72-6/Growth Hormone; EC 5-alpha-Reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Sexual function after bilateral retroperitoneal lymph node dissection for nonseminomatous testicular...
Next Document:  Effects of perfluorochemical emulsion components on human albumin binding of warfarin.