| Molecular battle between host and bacterium: recognition in innate immunity. | |
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MedLine Citation:
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PMID: 22038814 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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During infection, our innate immune system is the first line of defense and has evolved to clear invading bacteria immediately. To do so, recognition is the key element. However, how does the innate immune system distinguish self from nonself, and how does it recognize all bacteria (estimated to be far over a million species)? The answer lies in the recognition of evolutionary conserved structures. In this review, we approach this phenomenon from the bacterial perspective. What are the evolutionary conserved structures in bacteria, and what strategies are there in the human innate immune system to sense these structures? We illustrate most examples both at the functional as well as at the molecular level. Furthermore, we highlight how pathogenic bacteria can evade this recognition to survive better in the human host which in turn can result in life-threatening diseases. Copyright © 2011 John Wiley & Sons, Ltd. |
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Authors:
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Bart W Bardoel; Jos A G Strijp |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of molecular recognition : JMR Volume: 24 ISSN: 1099-1352 ISO Abbreviation: J. Mol. Recognit. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9004580 Medline TA: J Mol Recognit Country: England |
Other Details:
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Languages: eng Pagination: 1077-86 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Medical Microbiology, UMC Utrecht, Utrecht, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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