Document Detail


Molecular basis for ultraviolet vision in invertebrates.
MedLine Citation:
PMID:  14645481     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Invertebrates are sensitive to a broad spectrum of light that ranges from UV to red. Color sensitivity in the UV plays an important role in foraging, navigation, and mate selection in both flying and terrestrial invertebrate animals. Here, we show that a single amino acid polymorphism is responsible for invertebrate UV vision. This residue (UV: lysine vs blue:asparagine or glutamate) corresponds to amino acid position glycine 90 (G90) in bovine rhodopsin, a site affected in autosomal dominant human congenital night blindness. Introduction of the positively charged lysine in invertebrates is likely to deprotonate the Schiff base chromophore and produce an UV visual pigment. This same position is responsible for regulating UV versus blue sensitivity in several bird species, suggesting that UV vision has arisen independently in invertebrate and vertebrate lineages by a similar molecular mechanism.
Authors:
Ernesto Salcedo; Lijun Zheng; Meridee Phistry; Eve E Bagg; Steven G Britt
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  23     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2003-12-16     Revised Date:  2010-09-20    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10873-8     Citation Subset:  IM    
Affiliation:
Department of Cell and Developmental Biology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Substitution
Animals
Animals, Genetically Modified
Cattle
Color Perception / genetics,  physiology*
Drosophila / genetics,  physiology*
Drosophila Proteins / chemistry,  genetics,  physiology
Electroretinography
Mutation
Polymorphism, Genetic / genetics
Retinal Pigments / chemistry,  genetics,  physiology
Rhodopsin / chemistry,  genetics,  physiology
Structure-Activity Relationship
Ultraviolet Rays*
Grant Support
ID/Acronym/Agency:
R01 EY010759-09/EY/NEI NIH HHS; R01-EY10759/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/Retinal Pigments; 9009-81-8/Rhodopsin
Comments/Corrections

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