Document Detail

Molecular basis of tissue-specific gene expression mediated by the runt domain transcription factor PEBP2/CBF.
MedLine Citation:
PMID:  10620014     Owner:  NLM     Status:  MEDLINE    
The Runt domain transcription factor PEBP2/CBF is a heterodimer of alpha and beta subunits. Of the three mammalian alpha subunit genes, which are homologues of the Drosophila gene runt, PEBP2alphaA/CBFA1 and PEBP2alphaB/AML1 are critical regulators of osteogenesis and haematopoiesis, respectively. A unique functional interaction between PEBP2alphaB/AML1 and Ets-1 was recently observed, and provides a clear example of context-dependent transcriptional regulation. An elaborate mechanism of cooperation between the two factors may represent a basis for tissue-specific gene expression, which is thought to be achieved by combinations of specific sets of transcription factors unique to each cell lineage or stage of differentiation. A possible molecular basis for the critical role(s) played by PEBP2/CBF in tissue determination is discussed in light of these observations.
Y Ito
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Genes to cells : devoted to molecular & cellular mechanisms     Volume:  4     ISSN:  1356-9597     ISO Abbreviation:  Genes Cells     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-28     Completed Date:  2000-02-28     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9607379     Medline TA:  Genes Cells     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  685-96     Citation Subset:  IM    
Laboratory of Cell Regulation, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
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MeSH Terms
DNA-Binding Proteins / genetics*,  metabolism*
Drosophila / genetics
Drosophila Proteins
Gene Expression Regulation*
Transcription Factor AP-2
Transcription Factors / genetics*,  metabolism*
Transcription, Genetic*
Reg. No./Substance:
0/AP-2 protein, Drosophila; 0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Transcription Factor AP-2; 0/Transcription Factors

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