Document Detail

Molecular basis for the peripheral nerve predilection of Mycobacterium leprae.
MedLine Citation:
PMID:  11173029     Owner:  NLM     Status:  MEDLINE    
Mycobacterium leprae, the causative organism of leprosy, has a unique predilection for Schwann cells, the glial cells of the peripheral nervous system. M. leprae invasion of Schwann cells leads to the neurological damage that underlies the sensory motor loss and subsequent deformity and disability associated with this disease. Recent studies have begun to elucidate the early events of M. leprae infection of Schwann cells on a molecular level, and the host and bacterial factors that determine the neural predilection of this bacterium. These advances have now provided novel insights into the mechanisms of bacterial interactions with host cells.
A Rambukkana
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current opinion in microbiology     Volume:  4     ISSN:  1369-5274     ISO Abbreviation:  Curr. Opin. Microbiol.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-05-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9815056     Medline TA:  Curr Opin Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  21-7     Citation Subset:  IM    
Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
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MeSH Terms
Antigens, Bacterial / metabolism
Cell Wall / metabolism
Cytoskeletal Proteins / metabolism*
Glycolipids / metabolism
Laminin / metabolism
Leprosy / microbiology,  pathology*
Membrane Glycoproteins / metabolism*
Models, Biological
Mycobacterium leprae / pathogenicity*
Peripheral Nerves / microbiology*
Protein Binding
Schwann Cells / microbiology*
Grant Support
R01 A145816//PHS HHS
Reg. No./Substance:
0/Antigens, Bacterial; 0/Cytoskeletal Proteins; 0/DAG1 protein, human; 0/Glycolipids; 0/Laminin; 0/Membrane Glycoproteins; 0/phenolic glycolipid I, Mycobacterium leprae; 146888-27-9/Dystroglycans

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