Document Detail


Molecular basis of lipid antigen presentation by CD1d and recognition by natural killer T cells.
MedLine Citation:
PMID:  23046129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Together with peptides, T lymphocytes respond to hydrophobic molecules, mostly lipids, presented by the non-classical CD1 family (CD1a-e). These molecules have evolved complex and diverse binding grooves in order to survey different cellular compartments for self and exogenous antigens, which are then presented for recognition to T-cell receptors (TCRs) on the surface of T cells. In particular, most CD1d-presented antigens are recognized by a population of lymphocytes denominated natural killer T (NKT) cells, characterized by a strong immunomodulatory potential. Among NKT cells, two major subsets (type I and type II NKT cells) have been described, based on their TCR repertoire and antigen specificity. Here we review recent structural and biochemical studies that have shed light on the molecular details of CD1d-mediated antigen recognition by type I and II NKT cells, which are in many aspects distinct from what has been observed for peptide major histocompatibility complex-reactive TCRs.
Authors:
Enrico Girardi; Dirk M Zajonc
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  250     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-10     Completed Date:  2013-02-25     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  167-79     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigen-Presenting Cells / cytology,  immunology*,  metabolism
Antigens / chemistry*,  immunology,  metabolism
Antigens, CD1d / chemistry*,  immunology,  metabolism
Binding Sites
Epitopes
Humans
Killer Cells, Natural / cytology,  immunology*,  metabolism
Lipids / chemistry*,  immunology
Mice
Models, Molecular
Protein Binding
Protein Conformation
Protein Multimerization
Receptors, Antigen, T-Cell / chemistry*,  immunology,  metabolism
Grant Support
ID/Acronym/Agency:
AI074952/AI/NIAID NIH HHS; R01 AI074952/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antigens; 0/Antigens, CD1d; 0/Epitopes; 0/Lipids; 0/Receptors, Antigen, T-Cell
Comments/Corrections

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