| Molecular basis of lipid antigen presentation by CD1d and recognition by natural killer T cells. | |
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MedLine Citation:
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PMID: 23046129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Together with peptides, T lymphocytes respond to hydrophobic molecules, mostly lipids, presented by the non-classical CD1 family (CD1a-e). These molecules have evolved complex and diverse binding grooves in order to survey different cellular compartments for self and exogenous antigens, which are then presented for recognition to T-cell receptors (TCRs) on the surface of T cells. In particular, most CD1d-presented antigens are recognized by a population of lymphocytes denominated natural killer T (NKT) cells, characterized by a strong immunomodulatory potential. Among NKT cells, two major subsets (type I and type II NKT cells) have been described, based on their TCR repertoire and antigen specificity. Here we review recent structural and biochemical studies that have shed light on the molecular details of CD1d-mediated antigen recognition by type I and II NKT cells, which are in many aspects distinct from what has been observed for peptide major histocompatibility complex-reactive TCRs. |
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Authors:
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Enrico Girardi; Dirk M Zajonc |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Immunological reviews Volume: 250 ISSN: 1600-065X ISO Abbreviation: Immunol. Rev. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-10 Completed Date: 2013-02-25 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7702118 Medline TA: Immunol Rev Country: England |
Other Details:
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Languages: eng Pagination: 167-79 Citation Subset: IM |
Copyright Information:
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© 2012 John Wiley & Sons A/S. |
Affiliation:
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Division of Cell Biology, La Jolla Institute for Allergy and Immunology, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigen-Presenting Cells / cytology, immunology*, metabolism Antigens / chemistry*, immunology, metabolism Antigens, CD1d / chemistry*, immunology, metabolism Binding Sites Epitopes Humans Killer Cells, Natural / cytology, immunology*, metabolism Lipids / chemistry*, immunology Mice Models, Molecular Protein Binding Protein Conformation Protein Multimerization Receptors, Antigen, T-Cell / chemistry*, immunology, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AI074952/AI/NIAID NIH HHS; R01 AI074952/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Antigens, CD1d; 0/Epitopes; 0/Lipids; 0/Receptors, Antigen, T-Cell |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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