Document Detail


Molecular basis of inflammation: relationships between catabolic cytokines, hormones, energy balance, and muscle.
MedLine Citation:
PMID:  18974242     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inflammation alters energy metabolism, macro- and micronutrient balances, and body composition. This review briefly describes the current understanding of how this happens, focusing on the effect of immune system activation on energy balance. Conversely, malnutrition also has a large impact on immune function, with both undernutrition (causing immune suppression) and overnutrition (causing inflammation) now well described. Improved understanding of the interplay of the immune system and metabolism can lead to new treatments for both cachexia and obesity.
Authors:
Ronenn Roubenoff
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  JPEN. Journal of parenteral and enteral nutrition     Volume:  32     ISSN:  0148-6071     ISO Abbreviation:  JPEN J Parenter Enteral Nutr     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2008-10-31     Completed Date:  2009-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804134     Medline TA:  JPEN J Parenter Enteral Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  630-2     Citation Subset:  IM    
Affiliation:
Immunology R&D, Biogen Idec, Cambridge, Massachusetts 02142, USA. Ronenn.Roubenoff@biogenidec.com
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MeSH Terms
Descriptor/Qualifier:
Body Composition / physiology*
Cachexia / metabolism
Cytokines / biosynthesis*,  physiology
Energy Metabolism / physiology*
Homeostasis
Hormones / physiology
Humans
Inflammation / immunology,  metabolism,  physiopathology*
Muscle, Skeletal / metabolism
Obesity / metabolism
Chemical
Reg. No./Substance:
0/Cytokines; 0/Hormones

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