| Molecular basis of inflammation: relationships between catabolic cytokines, hormones, energy balance, and muscle. | |
MedLine Citation:
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PMID: 18974242 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inflammation alters energy metabolism, macro- and micronutrient balances, and body composition. This review briefly describes the current understanding of how this happens, focusing on the effect of immune system activation on energy balance. Conversely, malnutrition also has a large impact on immune function, with both undernutrition (causing immune suppression) and overnutrition (causing inflammation) now well described. Improved understanding of the interplay of the immune system and metabolism can lead to new treatments for both cachexia and obesity. |
Authors:
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Ronenn Roubenoff |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: JPEN. Journal of parenteral and enteral nutrition Volume: 32 ISSN: 0148-6071 ISO Abbreviation: JPEN J Parenter Enteral Nutr Publication Date: 2008 Nov-Dec |
Date Detail:
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Created Date: 2008-10-31 Completed Date: 2009-02-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804134 Medline TA: JPEN J Parenter Enteral Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 630-2 Citation Subset: IM |
Affiliation:
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Immunology R&D, Biogen Idec, Cambridge, Massachusetts 02142, USA. Ronenn.Roubenoff@biogenidec.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Body Composition
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physiology* Cachexia / metabolism Cytokines / biosynthesis*, physiology Energy Metabolism / physiology* Homeostasis Hormones / physiology Humans Inflammation / immunology, metabolism, physiopathology* Muscle, Skeletal / metabolism Obesity / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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