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Molecular basis for the diagnosis and treatment of acute promyelocytic leukemia.
MedLine Citation:
PMID:  23049403     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Acute promyelocytic leukemia is characterized by gene rearrangements that always involve the retinoic acid receptor alpha on chromosome 15. In the majority of patients t(15;17) is detected, which generates the promyelocytic leukemia gene/retinoic acid receptor alpha rearrangement. This rearrangement interacts with several proteins, including the native promyelocytic leukemia gene, thus causing its delocalization from the nuclear bodies, impairing its function. The immunofluorescence staining technique using the anti-PML antibody may be used to provide a rapid diagnosis and to immediately start therapy using all-trans retinoic acid. The experience of the International Consortium on Acute Promyelocytic Leukemia has demonstrated that early mortality was significantly reduced by adopting the immunofluorescence technique. All-trans retinoic acid combined with chemotherapy is the standard therapy; this promotes complete remission rates greater than 90% and cure rates of nearly 80%. However, early mortality is still an important limitation and hematologists must be aware of the importance of treating newly diagnosed acute promyelocytic leukemia as a medical emergency.
Authors:
Sarah Cristina Bassi; Eduardo Magalhães Rego
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Revista brasileira de hematologia e hemoterapia     Volume:  34     ISSN:  1806-0870     ISO Abbreviation:  Rev Bras Hematol Hemoter     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-10     Completed Date:  2012-10-11     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101220159     Medline TA:  Rev Bras Hematol Hemoter     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  134-9     Citation Subset:  -    
Affiliation:
Hematology and Oncology Division, Medical School of Ribeirão Preto, Universidade de São Paulo - USP, Ribeirão Preto, SP, Brazil.
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