Document Detail


Molecular basis of asbestos-induced lung disease.
MedLine Citation:
PMID:  23347351     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Asbestos causes asbestosis and malignancies by molecular mechanisms that are not fully understood. The modes of action underlying asbestosis, lung cancer, and mesothelioma appear to differ depending on the fiber type, lung clearance, and genetics. After reviewing the key pathologic changes following asbestos exposure, we examine recently identified pathogenic pathways, with a focus on oxidative stress. Alveolar epithelial cell apoptosis, which is an important early event in asbestosis, is mediated by mitochondria- and p53-regulated death pathways and may be modulated by the endoplasmic reticulum. We review mitochondrial DNA (mtDNA)-damage and -repair mechanisms, focusing on 8-oxoguanine DNA glycosylase, as well as cross talk between reactive oxygen species production, mtDNA damage, p53, OGG1, and mitochondrial aconitase. These new insights into the molecular basis of asbestos-induced lung diseases may foster the development of novel therapeutic targets for managing degenerative diseases (e.g., asbestosis and idiopathic pulmonary fibrosis), tumors, and aging, for which effective management is lacking.
Authors:
Gang Liu; Paul Cheresh; David W Kamp
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Annual review of pathology     Volume:  8     ISSN:  1553-4014     ISO Abbreviation:  Annu Rev Pathol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-25     Completed Date:  2013-04-09     Revised Date:  2014-01-27    
Medline Journal Info:
Nlm Unique ID:  101275111     Medline TA:  Annu Rev Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  161-87     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / drug effects
Asbestos / chemistry,  poisoning*,  toxicity*
Asbestosis / etiology*,  genetics,  metabolism,  pathology*
DNA Damage
DNA, Mitochondrial / drug effects
Humans
Lung Diseases / etiology*,  genetics,  metabolism,  pathology*
Lung Neoplasms / etiology,  genetics,  metabolism,  pathology
Mesothelioma / etiology,  genetics,  metabolism,  pathology
Oxidative Stress / drug effects
Reactive Oxygen Species / metabolism
Grant Support
ID/Acronym/Agency:
I01 BX000786/BX/BLRD VA; R01 ES020357/ES/NIEHS NIH HHS; R01ES020357/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Mitochondrial; 0/Reactive Oxygen Species; 1332-21-4/Asbestos
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pathogenesis of antineutrophil cytoplasmic autoantibody-associated small-vessel vasculitis.
Next Document:  The immunobiology and pathophysiology of primary biliary cirrhosis.