Document Detail

Molecular attributes of dopamine receptors: new potential for antipsychotic drug development.
MedLine Citation:
PMID:  8811164     Owner:  NLM     Status:  MEDLINE    
The neurotransmitter dopamine (DA) plays a central role in the control of motor function, emotional states, and endocrine physiology. The discovery that schizophrenic symptoms can be alleviated by neuroleptic drugs and the finding that these drugs interact at dopamine receptors has indicated involvement of the dopamine system in schizophrenia. The dopamine system has recently been shown to rely on the activation of five distinct subtypes of DA receptors (D1-D5) identified by molecular cloning, and pharmacological studies have specifically implicated the D2-like receptors (D2R, D3R and D4R) in antipsychotic action. In addition, the localization of D3R and D4R expression in the mesolimbic/mesocortical DA pathways is consistent with their proposed involvement in affective behaviour, and suggests that drugs developed specifically for these receptor subtypes might have potent antipsychotic activity with a lower propensity for extrapyramidal, endocrine, and cognitive side-effects.
D S Hartman; O Civelli
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of medicine     Volume:  28     ISSN:  0785-3890     ISO Abbreviation:  Ann. Med.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-12-04     Completed Date:  1996-12-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8906388     Medline TA:  Ann Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  211-9     Citation Subset:  IM    
Pharma Research, Preclinical Neurosciences, F. Hoffmann-La Roche AG, Basel, Switzerland.
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MeSH Terms
Antipsychotic Agents / pharmacology*,  therapeutic use
Receptors, Dopamine* / drug effects,  metabolism
Schizophrenia* / drug therapy,  physiopathology
Reg. No./Substance:
0/Antipsychotic Agents; 0/Receptors, Dopamine

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