Document Detail

Molecular aspects of ultraviolet radiation-induced apoptosis in the skin.
MedLine Citation:
PMID:  16699907     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Apoptosis, or programmed cell death, is an essential physiological process that controls cell numbers during physiological processes, and eliminates abnormal cells that can potentially harm an organism. OBJECTIVE: This review summarizes our current state of knowledge of apoptosis induction in skin by UV radiation. METHODS: A review of the literature was undertaken focusing on cell death in the skin secondary to UV radiation. RESULTS: It is evident that a number of apoptotic pathways, both intrinsic and extrinsic, are induced following exposure to damaging UV radiation. CONCLUSION: Although our understanding of the apoptotic processes is gradually increasing, many important aspects remain obscure. These include interconnections between pathways, wavelength-specific differences and cell type differences.
Jeffrey Chow; Victor A Tron
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cutaneous medicine and surgery     Volume:  9     ISSN:  1203-4754     ISO Abbreviation:  J Cutan Med Surg     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-10-03     Completed Date:  2006-10-20     Revised Date:  2007-07-04    
Medline Journal Info:
Nlm Unique ID:  9614685     Medline TA:  J Cutan Med Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  289-95     Citation Subset:  IM    
Department of Laboratory Medicine and Pathology, 4B1.19 Walter C Mackenzie Health Science Centre, University of Alberta, Edmonton, AB, Canada.
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MeSH Terms
Apoptosis / genetics*,  physiology,  radiation effects*
Cells, Cultured
DNA Damage / physiology
DNA Repair / physiology
Keratinocytes / cytology,  pathology,  radiation effects
Neoplasms, Radiation-Induced / epidemiology,  etiology*,  genetics
Reactive Oxygen Species
Signal Transduction
Skin / cytology,  radiation effects*
Skin Neoplasms / epidemiology,  etiology*,  genetics,  prevention & control
Tumor Necrosis Factors
Tumor Suppressor Protein p53 / genetics
Ultraviolet Rays / adverse effects*
Reg. No./Substance:
0/Reactive Oxygen Species; 0/Tumor Necrosis Factors; 0/Tumor Suppressor Protein p53

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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