Document Detail

Molecular aspects of preeclampsia.
MedLine Citation:
PMID:  17412411     Owner:  NLM     Status:  MEDLINE    
Various hypotheses as to the origin of preeclampsia have been explored over time. Diseases of pregnancy are difficult to study for several reasons. One limitation is due to the fact that preeclampsia and associated diseases clinically present in the second and third trimenon, but seem to originate early in pregnancy. Comparisons with animal models are difficult due to the unique human nature of the disease. The creation of new methods including proteomics, genomics, lipidomics, metabolomics or mRNA microarray techniques supplement the traditional type of research access to approach mother and fetus. The clinical course will be discussed and pregnancy-related processes, which are thought to contribute to the disease. This includes implantation of the placenta/fetus, the adaptation of the endothelial activity to the pregnancy with respect to relaxin, matrix metalloproteinases and endothelin, nitric oxide, angiogenetic factors and TGF-b in normal and preeclamptic pregnancies. Furthermore, oxidative stress, genetics and hypothesis-generating molecular approaches are considered.
Markus Mohaupt
Publication Detail:
Type:  Journal Article; Review     Date:  2007-02-24
Journal Detail:
Title:  Molecular aspects of medicine     Volume:  28     ISSN:  0098-2997     ISO Abbreviation:  Mol. Aspects Med.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-06-05     Completed Date:  2007-08-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603128     Medline TA:  Mol Aspects Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  169-91     Citation Subset:  IM    
Division of Hypertension, Department of Nephrology/Hypertension, University of Berne, Berne, Switzerland.
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MeSH Terms
Genomics / methods
Models, Biological
Oligonucleotide Array Sequence Analysis
Pre-Eclampsia / genetics*,  metabolism*,  pathology
Proteomics / methods

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