| Molecular aspects of human FcgammaR interactions with IgG: functional and therapeutic consequences. | |
| | |
MedLine Citation:
|
PMID: 16797726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The binding of IgG antibodies to receptors for the Fc region of IgG (FcgammaR) is a critical step for the initiation and/or the control of effector immune functions once immune complexes have been formed. Site-directed and random mutagenesis as well as domain-swapping, NMR and X-ray cristallography have made it possible to get detailed insights in the molecular mechanisms that govern IgG/FcgammaR interactions and to define some of the structural determinants that impact IgG binding to the various FcgammaR. It has demonstrated the role of particular stretches and individual residues located in the lower hinge region of the CH2 domain and in the CH2 and CH3 domains of the Fc region. The importance of the sugar components linked to asparagine 297 in the binding properties of IgG1, the human IgG isotype the most widely used in antibody-based therapies, has been also highlighted. These data have led to the engineering of a new generation of monoclonal antibodies for therapeutic use with optimized effector functions. |
| | |
Authors:
|
Sophie Sibéril; Charles-Antoine Dutertre; Charlotte Boix; Emmanuelle Bonnin; Renée Ménez; Enrico Stura; Sylvie Jorieux; Wolf-Herman Fridman; Jean-Luc Teillaud |
Related Documents
:
|
19592496 - A monomeric chicken igy receptor binds igy with 2:1 stoichiometry. 12618486 - Evidence of allosteric conformational changes in the antibody constant region upon anti... 8133076 - Receptor-mediated label-transfer assay (relay): a novel method for the detection of pla... 20025916 - Efficient selection of igg fc domain-binding peptides fused to fluorescent protein usin... 18194156 - Dissecting the components of quinine accumulation in plasmodium falciparum. 19473976 - Studies on the dids-binding site of monocarboxylate transporter 1 suggest a homology mo... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2006-06-12 |
Journal Detail:
|
Title: Immunology letters Volume: 106 ISSN: 0165-2478 ISO Abbreviation: Immunol. Lett. Publication Date: 2006 Aug |
Date Detail:
|
Created Date: 2006-08-21 Completed Date: 2006-10-31 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7910006 Medline TA: Immunol Lett Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 111-8 Citation Subset: IM |
Affiliation:
|
Unité INSERM 255, IFR58, Université René Descartes-Paris 5, Université Pierre et Marie Curie-Paris 6, Centre de Recherches Biomédicales des Cordeliers, Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antibodies, Monoclonal
/
genetics,
immunology*,
therapeutic use Humans Immunoglobulin Fc Fragments / genetics, immunology*, therapeutic use Immunoglobulin G / genetics, immunology*, therapeutic use Mutagenesis, Site-Directed / methods Protein Binding / genetics, immunology Receptors, Fc / genetics, immunology* |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Monoclonal; 0/Immunoglobulin Fc Fragments; 0/Immunoglobulin G; 0/Receptors, Fc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Extensive analysis of different allelelic structures of the chicken BF2 and beta2m proteins.
Next Document: Bimodal effect of nitric oxide in the enzymatic activity of indoleamine 2,3-dioxygenase in human mon...